Rastreamento de pessoas com HIV
O rastreamento de antígeno polissacarídeo criptocócico (CrAg) no sangue é recomendado para pessoas que vivem com HIV com contagem de CD4 de 100 células/mm³.[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. July 2021 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis?view=full
[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. June 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
[32]Chang CC, Harrison TS, Bicanic TA, et al. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis. 9 Feb 2024 [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/38346436?tool=bestpractice.com
Pode-se também considerar o rastreamento de CrAg com um limiar de contagem de CD4 mais elevado <200 células/microlitro.[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. June 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
De acordo com a OMS, quando o teste de CrAg de um paciente é positivo, a primeira consideração deve ser determinar se ele apresenta sinais/sintomas de meningite. Se houver suspeita de meningite, o paciente deve ser submetido a punção lombar para determinar se ele tem meningite criptocócica.[23]World Health Organization. Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. June 2022 [internet publication].
https://www.who.int/publications/i/item/9789240052178
Nos EUA, o rastreamento de CrAg sérico de rotina é recomendado para pessoas que atendam aos seguintes critérios:[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. July 2021 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis?view=full
Novo diagnóstico de HIV, e
Nenhum sinal clínico evidente de meningite, e
Contagem de CD4 ≤100 células/mm³, principalmente naqueles com contagem de CD4 ≤50 células/mm³.
As diretrizes dos EUA recomendam punção lombar em todas as pessoas HIV-positivas com teste de CrAg sérico positivo.[20]Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: cryptococcosis. July 2021 [internet publication].
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cryptococcosis?view=full