Trombocitemia essencial

O desenvolvimento de LMA é raro; o risco cumulativo em 15 anos varia de 2% a 5.3%.[70]Barbui T, Thiele J, Passamonti F, et al. Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol. 2011 Aug 10;29(23):3179-84. http://www.ncbi.nlm.nih.gov/pubmed/21747083?tool=bestpractice.com [71]Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J. 2015 Nov 13;5:e366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670948 http://www.ncbi.nlm.nih.gov/pubmed/26565403?tool=bestpractice.com [72]Passamonti F, Rumi E, Pungolino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med. 2004 Nov 15;117(10):755-61. http://www.ncbi.nlm.nih.gov/pubmed/15541325?tool=bestpractice.com

Leucemia mieloide aguda

O desenvolvimento de mielofibrose é raro; o risco cumulativo em 15 anos varia de 4% a 11%.[70]Barbui T, Thiele J, Passamonti F, et al. Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol. 2011 Aug 10;29(23):3179-84. http://www.ncbi.nlm.nih.gov/pubmed/21747083?tool=bestpractice.com [71]Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J. 2015 Nov 13;5:e366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670948 http://www.ncbi.nlm.nih.gov/pubmed/26565403?tool=bestpractice.com [72]Passamonti F, Rumi E, Pungolino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med. 2004 Nov 15;117(10):755-61. http://www.ncbi.nlm.nih.gov/pubmed/15541325?tool=bestpractice.com

Mielofibrose

A trombose está relacionada a alterações plaquetárias qualitativas e quantitativas. Os eventos trombóticos podem incluir AVC, ataques isquêmicos transitórios, oclusões da artéria retiniana ou venosas, oclusão da artéria coronária, embolia pulmonar, trombose da veia porta ou hepática, trombose venosa profunda e isquemia digital.[6]Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br J Haematol. 2005 Feb;128(3):275-90. https://www.doi.org/10.1111/j.1365-2141.2004.05277.x http://www.ncbi.nlm.nih.gov/pubmed/15667529?tool=bestpractice.com ​

Associado a trombocitose extrema.

Pode complicar a gestação.​[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com ​

Pode complicar a gestação.​[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com ​

Pode complicar a gestação.[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com [73]Griesshammer M, Heimpel H, Pearson TC. Essential thrombocythemia and pregnancy. Leuk Lymphoma. 1996 Sep;22(suppl 1):57-63. http://www.ncbi.nlm.nih.gov/pubmed/8951773?tool=bestpractice.com