A prevalência da encefalopatia de Wernicke, de acordo com estudos de autópsia não selecionados, varia em todo o mundo de 0.8% a 2.8%.[14]Harper C, Fornes P, Duyckaerts C, et al. An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. Metab Brain Dis. 1995 Mar;10(1):17-24.
http://www.ncbi.nlm.nih.gov/pubmed/7596325?tool=bestpractice.com
[15]Torvik A. Wernicke's encephalopathy: prevalence and clinical spectrum. Alcohol Alcohol Suppl. 1991;1:381-4.
http://www.ncbi.nlm.nih.gov/pubmed/1845567?tool=bestpractice.com
De acordo com estudos clínicos, esse número é menor, entre 0.04% e 0.13%, refletindo, talvez, o subdiagnóstico dessa doença.[16]Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry. 1986 Apr;49(4):341-5.
http://www.ncbi.nlm.nih.gov/pubmed/3701343?tool=bestpractice.com
[17]Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome: a clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser. 1971;7:1-206.
http://www.ncbi.nlm.nih.gov/pubmed/5162155?tool=bestpractice.com
A encefalopatia de Wernicke tem maior prevalência em pacientes com história de dependência alcoólica (12.5%), AIDS (10%) e transplante de medula óssea (6%).[18]Torvik A, Lindboe CF, Rogde S. Brain lesions in alcoholics: a neuropathological study with clinical correlations. J Neurol Sci.1982 Nov;56(2-3):233-48.
http://www.ncbi.nlm.nih.gov/pubmed/7175549?tool=bestpractice.com
[19]Boldorini R, Vago L, Lechi A, et al. Wernicke's encephalopathy: occurrence and pathological aspects in a series of 400 AIDS patients. Acta Biomed Ateneo Parmense. 1992;63(1-2):43-9.
http://www.ncbi.nlm.nih.gov/pubmed/1340667?tool=bestpractice.com
[20]Bleggi-Torres LF, de Medeiros BC, Werner B, et al. Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. Bone Marrow Transplant. 2000 Feb;25(3):301-7.
http://www.ncbi.nlm.nih.gov/pubmed/10673702?tool=bestpractice.com
[21]Choi YJ, Park SJ, Kim JS, et al. Wernicke's encephalopathy following allogeneic hematopoietic stem cell transplantation. Korean J Hematol. 2010 Dec;45(4):279-81.
https://synapse.koreamed.org/articles/1032915
http://www.ncbi.nlm.nih.gov/pubmed/21253432?tool=bestpractice.com
Outros fatores de risco incluem desnutrição por qualquer causa, neoplasia maligna, cirurgia gastrointestinal (particularmente cirurgia bariátrica) e hiperêmese gravídica.[22]Nagarajan E, Rupareliya C, Bollu PC. Wernicke's encephalopathy as a rare complication of hyperemesis gravidarum: a case report and Review of literature. Cureus. 2018 May 9;10(5):e2597.
http://www.ncbi.nlm.nih.gov/pubmed/30013861?tool=bestpractice.com
[23]Sechi G, Serra A. Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007 May;6(5):442-55.
http://www.ncbi.nlm.nih.gov/pubmed/17434099?tool=bestpractice.com
A prevalência é maior em homens (razão de homens/mulheres de 1.7:1).[17]Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome: a clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser. 1971;7:1-206.
http://www.ncbi.nlm.nih.gov/pubmed/5162155?tool=bestpractice.com
Um estudo de registro nacional que investigou a incidência e a mortalidade da encefalopatia de Wernicke relatou uma incidência por 100,000 pessoas-ano de 3.7 em homens (IC de 95%: 3.4 a 3.9) e 1.2 em mulheres (IC de 95%: 1.1 a 1.3).[24]Palm A, Vataja R, Talaslahti T, et al. Incidence and mortality of alcohol-related dementia and Wernicke-Korsakoff syndrome: A nationwide register study. Int J Geriatr Psychiatry. 2022 Aug;37(8):10.1002/gps.5775.
https://onlinelibrary.wiley.com/doi/10.1002/gps.5775
http://www.ncbi.nlm.nih.gov/pubmed/35789035?tool=bestpractice.com
Esse achado é atribuído à maior frequência de transtornos decorrentes do uso de bebidas alcoólicas em homens; no entanto, a encefalopatia de Wernicke não relacionada a bebidas alcoólicas pode ser mais comum em mulheres.[25]Scalzo SJ, Bowden SC, Ambrose ML, et al. Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review. J Neurol Neurosurg Psychiatry. 2015 Dec;86(12):1362-8.
http://www.ncbi.nlm.nih.gov/pubmed/25589780?tool=bestpractice.com