A maioria dos pacientes, em geral, não apresenta nenhum sintoma, e o aneurisma é observado ao exame físico ou em exames de imagem realizados por outras razões.
História
Na minoria dos pacientes que apresentam sintomas, é comum haver dor abdominal, dorsalgia e na virilha. A história clínica é direcionada para os fatores de risco:
Desenvolvimento (ou seja, hiperlipidemia, doenças do tecido conjuntivo, DPOC e hipertensão)[1]Dehlin JM, Upchurch GR. Management of abdominal aortic aneurysms. Curr Treat Options Cardiovasc Med. 2005 Jun;7(2):119-30.
http://www.ncbi.nlm.nih.gov/pubmed/15935120?tool=bestpractice.com
[5]Isselbacher EM, Preventza O, Hamilton Black J 3rd, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022 Dec 13;146(24):e334-e482.
https://www.doi.org/10.1161/CIR.0000000000001106
http://www.ncbi.nlm.nih.gov/pubmed/36322642?tool=bestpractice.com
[13]Zankl AR, Schumacher H, Krumsdorf U, et al. Pathology, natural history and treatment of abdominal aortic aneurysms. Clin Res Cardiol. 2007 Mar;96(3):140-51.
http://www.ncbi.nlm.nih.gov/pubmed/17180573?tool=bestpractice.com
[15]Singh K, Bønaa H, Jacobsen BK, et al. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study: the Tromsø Study. Am J Epidemiol. 2001 Aug 1;154(3):236-44.
https://academic.oup.com/aje/article/154/3/236/125840
http://www.ncbi.nlm.nih.gov/pubmed/11479188?tool=bestpractice.com
[22]Lederle FA, Johnson GR, Wilson SE, et al; Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Prevalence and associations of abdominal aortic aneurysm detected through screening. Ann Intern Med. 1997 Mar 15;126(6):441-9.
http://www.ncbi.nlm.nih.gov/pubmed/9072929?tool=bestpractice.com
[58]Jeremy RW, Huang H, Hwa J, et al. Relation between age, arterial distensibility, and aortic dilatation in the Marfan syndrome. Am J Cardiol. 1994 Aug 15;74(4):369-73.
http://www.ncbi.nlm.nih.gov/pubmed/8059700?tool=bestpractice.com
[59]McConathy WJ, Alaupovic P, Woolcock N, et al. Lipids and apolipoprotein profiles in men with aneurysmal and stenosing aorto-iliac atherosclerosis. Eur J Vasc Surg. 1989 Dec;3(6):511-4.
http://www.ncbi.nlm.nih.gov/pubmed/2625160?tool=bestpractice.com
[63]Fowkes FG, Anandan CL, Lee AJ, et al. Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease. J Vasc Surg. 2006 Mar;43(3):474-80.
http://www.ncbi.nlm.nih.gov/pubmed/16520158?tool=bestpractice.com
[70]Takagi H, Umemoto T; ALICE (All-Literature Investigation of Cardiovascular Evidence) Group. A meta-analysis of the association of chronic obstructive pulmonary disease with abdominal aortic aneurysm presence. Ann Vasc Surg. 2016 Jul;34:84-94.
http://www.ncbi.nlm.nih.gov/pubmed/27189132?tool=bestpractice.com
Expansão (ou seja, transplante cardíaco ou renal prévio, AVC prévio, idade avançada (>70 anos) e doença cardíaca grave)[71]Keisler B, Carter C. Abdominal aortic aneurysm. Am Fam Physician. 2015 Apr 15;91(8):538-43.
https://www.aafp.org/afp/2015/0415/p538.html
http://www.ncbi.nlm.nih.gov/pubmed/25884861?tool=bestpractice.com
[72]Chang JB, Stein TA, Liu JP, et al. Risk factors associated with rapid growth of small abdominal aortic aneurysms. Surgery. 1997 Feb;121(2):117-22.
http://www.ncbi.nlm.nih.gov/pubmed/9037221?tool=bestpractice.com
[73]Englesbe MJ, Wu AH, Clowes AW, et al. The prevalence and natural history of aortic aneurysms in heart and abdominal organ transplant patients. J Vasc Surg. 2003 Jan;37(1):27-31.
https://www.jvascsurg.org/article/S0741-5214(02)75198-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/12514574?tool=bestpractice.com
Ruptura (ou seja, sexo feminino, transplante cardíaco ou renal prévio, hipertensão).[13]Zankl AR, Schumacher H, Krumsdorf U, et al. Pathology, natural history and treatment of abdominal aortic aneurysms. Clin Res Cardiol. 2007 Mar;96(3):140-51.
http://www.ncbi.nlm.nih.gov/pubmed/17180573?tool=bestpractice.com
[54]Skibba AA, Evans JR, Hopkins SP, et al. Reconsidering gender relative to risk of rupture in the contemporary management of abdominal aortic aneurysms. J Vasc Surg. 2015 Dec;62(6):1429-36.
https://www.jvascsurg.org/article/S0741-5214(15)01689-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/26409846?tool=bestpractice.com
[55]Gokani VJ, Sidloff D, Bath MF, et al. A retrospective study: factors associated with the risk of abdominal aortic aneurysm rupture. Vascul Pharmacol. 2015 Feb-Mar;65-66:13-6.
http://www.ncbi.nlm.nih.gov/pubmed/25485708?tool=bestpractice.com
[73]Englesbe MJ, Wu AH, Clowes AW, et al. The prevalence and natural history of aortic aneurysms in heart and abdominal organ transplant patients. J Vasc Surg. 2003 Jan;37(1):27-31.
https://www.jvascsurg.org/article/S0741-5214(02)75198-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/12514574?tool=bestpractice.com
[74]Brown LC, Powell JT. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. Ann Surg. 1999 Sep;230(3):289-96.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420874
http://www.ncbi.nlm.nih.gov/pubmed/10493476?tool=bestpractice.com
[75]Upchurch GR, Schaub TA. Abdominal aortic aneurysm. Am Fam Physician. 2006 Apr 1;73(7):1198-204.
https://www.aafp.org/afp/2006/0401/p1198.html
http://www.ncbi.nlm.nih.gov/pubmed/16623206?tool=bestpractice.com
Uma história de tabagismo aumenta o risco de desenvolvimento de aneurisma da aorta abdominal (AAA), expansão e ruptura.[5]Isselbacher EM, Preventza O, Hamilton Black J 3rd, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022 Dec 13;146(24):e334-e482.
https://www.doi.org/10.1161/CIR.0000000000001106
http://www.ncbi.nlm.nih.gov/pubmed/36322642?tool=bestpractice.com
[13]Zankl AR, Schumacher H, Krumsdorf U, et al. Pathology, natural history and treatment of abdominal aortic aneurysms. Clin Res Cardiol. 2007 Mar;96(3):140-51.
http://www.ncbi.nlm.nih.gov/pubmed/17180573?tool=bestpractice.com
[22]Lederle FA, Johnson GR, Wilson SE, et al; Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Prevalence and associations of abdominal aortic aneurysm detected through screening. Ann Intern Med. 1997 Mar 15;126(6):441-9.
http://www.ncbi.nlm.nih.gov/pubmed/9072929?tool=bestpractice.com
[23]Wilmink TB, Quick CR, Day NE. The association between cigarette smoking and abdominal aortic aneurysms. J Vasc Surg. 1999 Dec;30(6):1099-105.
http://www.ncbi.nlm.nih.gov/pubmed/10587395?tool=bestpractice.com
[43]Rasmussen TE, Hallett JW Jr, Tazelaar HD, et al. Human leukocyte antigen class II immune response genes, female gender, and cigarette smoking as risk and modulating factors in abdominal aortic aneurysms. J Vasc Surg. 2002 May;35(5):988-93.
http://www.ncbi.nlm.nih.gov/pubmed/12021716?tool=bestpractice.com
[75]Upchurch GR, Schaub TA. Abdominal aortic aneurysm. Am Fam Physician. 2006 Apr 1;73(7):1198-204.
https://www.aafp.org/afp/2006/0401/p1198.html
http://www.ncbi.nlm.nih.gov/pubmed/16623206?tool=bestpractice.com
Em homens que nunca fumaram, importantes fatores de risco para aneurisma da aorta abdominal (AAA) incluem idade avançada e um parente de primeiro grau com AAA.[3]Wanhainen A, Van Herzeele I, Bastos Goncalves F, et al. Editor's choice -- European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg. 2024 Feb;67(2):192-331.
https://www.ejves.com/article/S1078-5884(23)00889-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38307694?tool=bestpractice.com
[4]Owens DK, Davidson KW, Krist AH, et al; US Preventive Services Task Force. Screening for abdominal aortic aneurysm: US Preventive Services Task Force recommendation statement. JAMA. 2019 Dec 10;322(22):2211-8.
https://jamanetwork.com/journals/jama/fullarticle/2757234
http://www.ncbi.nlm.nih.gov/pubmed/31821437?tool=bestpractice.com
História de cirurgia abdominal prévia ou reparo de aneurisma da aorta endovascular prévio pode ser obtida, bem como história familiar de AAA.
Exame físico
O abdome pode ser apalpado em busca de uma massa abdominal pulsátil e sensibilidade abdominal. O exame físico deve incluir uma avaliação da presença de aneurisma das artérias periféricas (femoral e poplítea).[76]Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018 Jan;67(1):2-77.e2.
https://www.jvascsurg.org/article/S0741-5214(17)32369-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/29268916?tool=bestpractice.com
A palpação do aneurisma no exame clínico só demonstrou ser sensível em pacientes magros e naqueles com AAA >5 cm, com sensibilidade e especificidade globais de 68% e 75%, respectivamente.[1]Dehlin JM, Upchurch GR. Management of abdominal aortic aneurysms. Curr Treat Options Cardiovasc Med. 2005 Jun;7(2):119-30.
http://www.ncbi.nlm.nih.gov/pubmed/15935120?tool=bestpractice.com
[77]Fink HA, Lederle FA, Roth CS, et al. The accuracy of physical examination to detect abdominal aortic aneurysm. Arch Intern Med. 2000 Mar 27;160(6):833-6.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485262
http://www.ncbi.nlm.nih.gov/pubmed/10737283?tool=bestpractice.com
As taxas de detecção são afetadas pelo diâmetro da aorta, pela experiência do médico e pelo hábito corporal do paciente.[3]Wanhainen A, Van Herzeele I, Bastos Goncalves F, et al. Editor's choice -- European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg. 2024 Feb;67(2):192-331.
https://www.ejves.com/article/S1078-5884(23)00889-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38307694?tool=bestpractice.com
A sensibilidade da palpação abdominal para detecção de AAA diminui em pacientes com circunferência abdominal maior que 100 cm.[77]Fink HA, Lederle FA, Roth CS, et al. The accuracy of physical examination to detect abdominal aortic aneurysm. Arch Intern Med. 2000 Mar 27;160(6):833-6.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485262
http://www.ncbi.nlm.nih.gov/pubmed/10737283?tool=bestpractice.com
A tríade clássica de massa abdominal pulsátil com hipotensão e dor abdominal e/ou dorsalgia está presente em cerca de 50% dos pacientes com AAA roto.[3]Wanhainen A, Van Herzeele I, Bastos Goncalves F, et al. Editor's choice -- European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg. 2024 Feb;67(2):192-331.
https://www.ejves.com/article/S1078-5884(23)00889-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38307694?tool=bestpractice.com
A presença de febre pode aumentar a suspeita de AAA infeccioso no contexto clínico apropriado.
Testes decisivos
A suspeita de AAA rompido ou sintomático é uma emergência médica; é necessária revisão imediata de um cirurgião vascular. Consulte Abordagem de tratamento. Exames de imagem urgentes com ultrassonografia aórtica à beira do leito são necessários para confirmar o diagnóstico; entretanto, o diagnóstico clínico e o manejo de um AAA roto não devem ser protelados enquanto se aguarda os resultados dos exames de imagem.[76]Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018 Jan;67(1):2-77.e2.
https://www.jvascsurg.org/article/S0741-5214(17)32369-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/29268916?tool=bestpractice.com
[78]National Institute for Health and Care Excellence. Abdominal aortic aneurysm: diagnosis and management. Mar 2020 [internet publication].
https://www.nice.org.uk/guidance/ng156
A ultrassonografia é realizada perpendicular ao eixo da aorta, pois as visões oblíquas podem superestimar o diâmetro real da aorta.[2]Chaikof EL, Blankensteijn JD, Harris PL, et al. Reporting standards for endovascular aortic aneurysm repair. J Vasc Surg. 2002 May;35(5):1048-60.
https://www.doi.org/10.1067/mva.2002.123763
http://www.ncbi.nlm.nih.gov/pubmed/12021727?tool=bestpractice.com
[5]Isselbacher EM, Preventza O, Hamilton Black J 3rd, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022 Dec 13;146(24):e334-e482.
https://www.doi.org/10.1161/CIR.0000000000001106
http://www.ncbi.nlm.nih.gov/pubmed/36322642?tool=bestpractice.com
[79]American College of Radiology. ACR Appropriateness Criteria: pulsatile abdominal mass, suspected abdominal aortic aneurysm. 2023 [internet publication].
https://acsearch.acr.org/docs/69414/Narrative
Infelizmente, a ultrassonografia é de pouca utilidade na geração de imagens de aneurismas perto das origens ou proximais às artérias renais.[80]Vowden P, Wilkinson D, Ausobsky JR, et al. A comparison of three imaging techniques in the assessment of an abdominal aortic aneurysm. J Cardiovasc Surg (Torino). 1989 Nov-Dec;30(6):891-6.
http://www.ncbi.nlm.nih.gov/pubmed/2689452?tool=bestpractice.com
[81]Taylor SM, Mills JL, Fujitani RM. The juxtarenal abdominal aortic aneurysm: a more common problem than previously realized? Arch Surg. 1994 Jul;129(7):734-7.
http://www.ncbi.nlm.nih.gov/pubmed/8024454?tool=bestpractice.com
Em pacientes selecionados, a TC é recomendada como investigação de primeira linha para avaliar pacientes com suspeita de AAA que apresentam dor abdominal ou nas costas de início recente, principalmente na presença de massa epigástrica pulsátil ou fatores de risco significativos para AAA.[76]Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018 Jan;67(1):2-77.e2.
https://www.jvascsurg.org/article/S0741-5214(17)32369-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/29268916?tool=bestpractice.com
Outras investigações
Uma vez realizado o diagnóstico, exames de imagem adicionais com angiotomografia (ATG) são usados para descartar a ruptura e para mapeamento anatômico para auxiliar no planejamento operatório (aberto ou endovascular).[78]National Institute for Health and Care Excellence. Abdominal aortic aneurysm: diagnosis and management. Mar 2020 [internet publication].
https://www.nice.org.uk/guidance/ng156
[79]American College of Radiology. ACR Appropriateness Criteria: pulsatile abdominal mass, suspected abdominal aortic aneurysm. 2023 [internet publication].
https://acsearch.acr.org/docs/69414/Narrative
[82]Truijers M, Resch T, Van Den Berg JC, et al. Endovascular aneurysm repair: state-of-art imaging techniques for preoperative planning and surveillance. J Cardiovasc Surg (Torino). 2009 Aug;50(4):423-38.
http://www.ncbi.nlm.nih.gov/pubmed/19734828?tool=bestpractice.com
A velocidade de hemossedimentação e proteína C-reativa elevadas suportam um diagnóstico de possível AAA inflamatório.[5]Isselbacher EM, Preventza O, Hamilton Black J 3rd, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022 Dec 13;146(24):e334-e482.
https://www.doi.org/10.1161/CIR.0000000000001106
http://www.ncbi.nlm.nih.gov/pubmed/36322642?tool=bestpractice.com
O teste para leucocitose e anemia relativa no hemograma completo com hemoculturas positivas é indicativo de AAA infeccioso.[12]Gomes MN, Choyke PL, Wallace RB. Infected aortic aneurysms: a changing entity. Ann Surg. 1992 May;215(5):435-42.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242469/pdf/annsurg00087-0057.pdf
http://www.ncbi.nlm.nih.gov/pubmed/1616380?tool=bestpractice.com
A tomografia por emissão de pósitrons/tomografia computadorizada (PET-CT) é usada para o diagnóstico e acompanhamento de patologias aórticas associadas a aneurismas inflamatórios, infecção aórtica (incluindo AAAs micóticos), próteses infectadas e enxertos de stent.[3]Wanhainen A, Van Herzeele I, Bastos Goncalves F, et al. Editor's choice -- European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg. 2024 Feb;67(2):192-331.
https://www.ejves.com/article/S1078-5884(23)00889-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38307694?tool=bestpractice.com
[83]Chakfé N, Diener H, Lejay A, et al. Editor's choice - European Society for Vascular Surgery (ESVS) 2020 clinical practice guidelines on the management of vascular graft and endograft infections. Eur J Vasc Endovasc Surg. 2020 Mar;59(3):339-84.
https://www.ejves.com/article/S1078-5884(19)32532-8/fulltext
Preditores do risco de ruptura incluem a taxa de expansão do AAA, aumento da espessura do trombo intraluminal, rigidez da parede, tensão da parede e intensidade máxima de estresse na parede do AAA.[10]Groeneveld ME, Meekel JP, Rubinstein SM, et al. Systematic review of circulating, biomechanical, and genetic markers for the prediction of abdominal aortic aneurysm growth and rupture. J Am Heart Assoc. 2018 Jun 30;7(13):29960996.
https://www.doi.org/10.1161/JAHA.117.007791
http://www.ncbi.nlm.nih.gov/pubmed/29960996?tool=bestpractice.com
[76]Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018 Jan;67(1):2-77.e2.
https://www.jvascsurg.org/article/S0741-5214(17)32369-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/29268916?tool=bestpractice.com
[84]Fillinger MF, Marra SP, Raghavan ML, et al. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003 Apr;37(4):724-32.
http://www.ncbi.nlm.nih.gov/pubmed/12663969?tool=bestpractice.com