O rastreamento de familiares de pacientes com hemocromatose é apoiado pela American Association for the Study of Liver Diseases, o American College of Gastroenterology, a British Society for Haematology e a European Association for the Study of the Liver.[4]Kowdley KV, Brown KE, Ahn J, et al. Correction: ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019 Dec;114(12):1927.
http://www.ncbi.nlm.nih.gov/pubmed/31724994?tool=bestpractice.com
[7]Kowdley KV, Brown KE, Ahn J, et al. ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019 Aug;114(8):1202-18.
https://journals.lww.com/ajg/fulltext/2019/08000/acg_clinical_guideline__hereditary_hemochromatosis.11.aspx
http://www.ncbi.nlm.nih.gov/pubmed/31335359?tool=bestpractice.com
[8]European Association for the Study of the Liver. EASL clinical practice guidelines on haemochromatosis. J Hepatol. 2022 Aug;77(2):479-502.
https://www.journal-of-hepatology.eu/article/S0168-8278(22)00211-2/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/35662478?tool=bestpractice.com
[54]Bacon BR, Adams PC, Kowdley KV, et al. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011 Jul;54(1):328-43.
http://onlinelibrary.wiley.com/doi/10.1002/hep.24330/full
http://www.ncbi.nlm.nih.gov/pubmed/21452290?tool=bestpractice.com
[55]Fitzsimons EJ, Cullis JO, Thomas DW, et al. Diagnosis and therapy of genetic haemochromatosis (review and 2017 update). Br J Haematol. 2018 May;181(3):293-303.
https://www.doi.org/10.1111/bjh.15164
http://www.ncbi.nlm.nih.gov/pubmed/29663319?tool=bestpractice.com
O rastreamento pode incluir saturação de transferrina em jejum, níveis de ferritina e/ou testes genéticos em familiares adultos, e o rastreamento é recomendado para irmãos e filhos de pacientes afetados. Entretanto, se o cônjuge de um paciente com hemocromatose não for um portador, os filhos não podem ser homozigotos para a mutação e, por isso, não precisam do teste.[78]Adams PC. Implications of genotyping of spouses to limit investigation of children in genetic hemochromatosis. Clin Genet. 1998 Mar;53(3):176-8.
http://www.ncbi.nlm.nih.gov/pubmed/9630070?tool=bestpractice.com
Os pacientes com hemocromatose devem ser aconselhados a evitar suplementação adicional de vitamina C e ferro; fontes naturais são consideradas aceitáveis.[4]Kowdley KV, Brown KE, Ahn J, et al. Correction: ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019 Dec;114(12):1927.
http://www.ncbi.nlm.nih.gov/pubmed/31724994?tool=bestpractice.com
[7]Kowdley KV, Brown KE, Ahn J, et al. ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019 Aug;114(8):1202-18.
https://journals.lww.com/ajg/fulltext/2019/08000/acg_clinical_guideline__hereditary_hemochromatosis.11.aspx
http://www.ncbi.nlm.nih.gov/pubmed/31335359?tool=bestpractice.com
[8]European Association for the Study of the Liver. EASL clinical practice guidelines on haemochromatosis. J Hepatol. 2022 Aug;77(2):479-502.
https://www.journal-of-hepatology.eu/article/S0168-8278(22)00211-2/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/35662478?tool=bestpractice.com
Alguns pacientes podem ser aconselhados a tomar baixas doses de vitamina C se estiverem sendo tratados com terapia quelante de ferro para aumentar a excreção de ferro.