Tumor de Wilms

Crianças com síndromes com aumento do risco de tumor de Wilms devem realizar uma ultrassonografia renal a cada 3 meses desde o nascimento até os 7 anos de idade.[31]Kalish JM, Doros L, Helman LJ, et al. Surveillance recommendations for children with overgrowth syndromes and predisposition to Wilms tumors and hepatoblastoma. Clin Cancer Res. 2017 Jul 1;23(13):e115-22. https://aacrjournals.org/clincancerres/article/23/13/e115/79988/Surveillance-Recommendations-for-Children-with http://www.ncbi.nlm.nih.gov/pubmed/28674120?tool=bestpractice.com [76]Hol JA, Jewell R, Chowdhury T, et al. Wilms tumour surveillance in at-risk children: literature review and recommendations from the SIOP-Europe Host Genome Working Group and SIOP Renal Tumour Study Group. Eur J Cancer. 2021 Aug;153:51-63. https://www.ejcancer.com/article/S0959-8049(21)00322-1/fulltext http://www.ncbi.nlm.nih.gov/pubmed/34134020?tool=bestpractice.com Deve-se prestar atenção principalmente à identificação de restos nefrogênicos que podem aumentar a probabilidade de evoluir para um tumor de Wilms.[77]Heppe RK, Koyle MA, Beckwith JB. Nephrogenic rests in Wilms tumor patients with the Drash syndrome. J Urol. 1991 Jun;145(6):1225-8. http://www.ncbi.nlm.nih.gov/pubmed/1851891?tool=bestpractice.com [78]Beckwith JB. Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations. Am J Med Genet. 1998 Oct 2;79(4):268-73. http://www.ncbi.nlm.nih.gov/pubmed/9781906?tool=bestpractice.com [79]Beckwith JB. Management of incidentally encountered nephrogenic rests. J Pediatr Hematol Oncol. 2007 Jun;29(6):353-4. http://www.ncbi.nlm.nih.gov/pubmed/17551393?tool=bestpractice.com Além disso, aconselhamento genético e pré-natal deve ser oferecido aos pais com história familiar.[32]Schienda J, Stopfer J. Cancer genetic counseling-current practice and future challenges. Cold Spring Harb Perspect Med. 2020 Jun 1;10(6):a036541. https://perspectivesinmedicine.cshlp.org/content/10/6/a036541.long http://www.ncbi.nlm.nih.gov/pubmed/31548230?tool=bestpractice.com [33]Turner JT, Brzezinski J, Dome JS. Wilms tumor predisposition. 2003 Dec 19 (updated 2022 Mar 24). In: Adam MP, Mirzaa GM, Pagon RA, et al, eds. GeneReviews [internet]. Seattle, WA: University of Washington, Seattle; 1993-2023. https://www.ncbi.nlm.nih.gov/books/NBK1294 http://www.ncbi.nlm.nih.gov/pubmed/20301471?tool=bestpractice.com