O abscesso epidural espinhal (AEE) é incomum. A incidência relatada aumentou ao longo das últimas três décadas: estudos iniciais relataram uma incidência de aproximadamente 0.2 a 2.0 casos por 10,000 internações hospitalares, mas as estimativas mais recentes estão ao redor de 2 a 12.5 casos por 10,000 internações.[2]Bond A, Manian FA. Spinal epidural abscess: a review with special emphasis on earlier diagnosis. Biomed Res Int. 2016 Dec 1 [Epub ahead of print].
https://www.hindawi.com/journals/bmri/2016/1614328
http://www.ncbi.nlm.nih.gov/pubmed/28044125?tool=bestpractice.com
[6]Turner A, Zhao L, Gauthier P, et al. Management of cervical spine epidural abscess: a systematic review. Ther Adv Infect Dis. 2019 Jul 19;6:2049936119863940.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643182
http://www.ncbi.nlm.nih.gov/pubmed/31367375?tool=bestpractice.com
[7]Grewal S, Hocking G, Wildsmith JA. Epidural abscesses. Br J Anaesth. 2006 Mar;96(3):292-302.
https://www.sciencedirect.com/science/article/pii/S0007091217351991?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/16431882?tool=bestpractice.com
[8]Vakili M, Crum-Cianflone NF. Spinal epidural abscess: a series of 101 cases. Am J Med. 2017 Dec;130(12):1458-63.
http://www.ncbi.nlm.nih.gov/pubmed/28797646?tool=bestpractice.com
[9]Sharfman ZT, Gelfand Y, Shah P, et al. Spinal epidural abscess: a review of presentation, management, and medicolegal implications. Asian Spine J. 2020 Oct;14(5):742-59.
https://www.asianspinejournal.org/journal/view.php?doi=10.31616/asj.2019.0369
http://www.ncbi.nlm.nih.gov/pubmed/32718133?tool=bestpractice.com
Esse aumento pode ocorrer em parte devido a um aumento genuíno nos fatores de risco específicos (por exemplo, cirurgia da coluna vertebral e uso de drogas intravenosas); o AEE após anestesia espinhal está aumentando nos países industrializados.[4]Osborne L, Snyder M, Villecco D, et al. Evidence-based anesthesia: fever of unknown origin in parturients and neuraxial anesthesia. AANA J. 2008 Jun;76(3):221-6.
http://www.ncbi.nlm.nih.gov/pubmed/18567328?tool=bestpractice.com
[5]Nussbaum ES, Rigamonti D, Standiford H, et al. Spinal epidural abscess: a report of 40 cases and review. Surg Neurol. 1992 Sep;38(3):225-31.
http://www.ncbi.nlm.nih.gov/pubmed/1359657?tool=bestpractice.com
No entanto, o aumento das detecções com o aperfeiçoamento dos exames de imagem (principalmente, ressonâncias nucleares magnéticas) provavelmente também contribuem para a maior incidência relatada.[2]Bond A, Manian FA. Spinal epidural abscess: a review with special emphasis on earlier diagnosis. Biomed Res Int. 2016 Dec 1 [Epub ahead of print].
https://www.hindawi.com/journals/bmri/2016/1614328
http://www.ncbi.nlm.nih.gov/pubmed/28044125?tool=bestpractice.com
[9]Sharfman ZT, Gelfand Y, Shah P, et al. Spinal epidural abscess: a review of presentation, management, and medicolegal implications. Asian Spine J. 2020 Oct;14(5):742-59.
https://www.asianspinejournal.org/journal/view.php?doi=10.31616/asj.2019.0369
http://www.ncbi.nlm.nih.gov/pubmed/32718133?tool=bestpractice.com
[10]Ezeh E, Akhigbe EJ, Simmons J, et al. Unsterile subcutaneous insulin injections causing psoas and spinal epidural abscesses. Cureus. 2021 Oct;13(10):e18715.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584058
http://www.ncbi.nlm.nih.gov/pubmed/34790470?tool=bestpractice.com
A taxa de prevalência de AEE mostra uma razão de homens/mulheres de 1.66:1; no entanto, isso provavelmente está relacionado à predominância dos fatores de risco e não a qualquer predileção em si.[9]Sharfman ZT, Gelfand Y, Shah P, et al. Spinal epidural abscess: a review of presentation, management, and medicolegal implications. Asian Spine J. 2020 Oct;14(5):742-59.
https://www.asianspinejournal.org/journal/view.php?doi=10.31616/asj.2019.0369
http://www.ncbi.nlm.nih.gov/pubmed/32718133?tool=bestpractice.com
Em uma metanálise, o AEE torácico representou 55% dos casos, o lombar 30% e o cervical 15%; 80% dos AEEs estavam situados no espaço epidural posterior, e 20% anteriormente.[11]Chao D, Nanda A. Spinal epidural abscess: a diagnostic challenge. Am Fam Physician. 2002 Apr 1;65(7):1341-6.
http://www.aafp.org/afp/20020401/1341.html
http://www.ncbi.nlm.nih.gov/pubmed/11996416?tool=bestpractice.com
O AEE geralmente ocorre nas regiões torácica e lombar devido ao maior espaço epidural, à abundância de gordura propensa a infecções e à presença de um sistema venoso vertebral de baixa pressão (plexo venoso de Batson) que se comunica livremente com os sistemas venosos abdominal e pélvico.[9]Sharfman ZT, Gelfand Y, Shah P, et al. Spinal epidural abscess: a review of presentation, management, and medicolegal implications. Asian Spine J. 2020 Oct;14(5):742-59.
https://www.asianspinejournal.org/journal/view.php?doi=10.31616/asj.2019.0369
http://www.ncbi.nlm.nih.gov/pubmed/32718133?tool=bestpractice.com
A infecção pode alcançar diferentes níveis anatômicos.
A mortalidade decorrente de AEE diminuiu; as taxas de mortalidade relatadas variam de 16% em uma metanálise publicada em 2000 a estimativas mais recentes de 3.7% a 11.8%.[9]Sharfman ZT, Gelfand Y, Shah P, et al. Spinal epidural abscess: a review of presentation, management, and medicolegal implications. Asian Spine J. 2020 Oct;14(5):742-59.
https://www.asianspinejournal.org/journal/view.php?doi=10.31616/asj.2019.0369
http://www.ncbi.nlm.nih.gov/pubmed/32718133?tool=bestpractice.com
[12]Reihsaus E, Waldbaur H, Seeling W. Spinal epidural abscess: a meta-analysis of 915 patients. Neurosurg Rev. 2000 Dec;23(4):175-204.
http://www.ncbi.nlm.nih.gov/pubmed/11153548?tool=bestpractice.com
[13]Du JY, Schell AJ, Kim CY, et al. 30-day mortality following surgery for spinal epidural abscess: incidence, risk factors, predictive algorithm, and associated complications. Spine (Phila Pa 1976). 2019 Apr 15;44(8):E500-09.
http://www.ncbi.nlm.nih.gov/pubmed/30234819?tool=bestpractice.com
[14]Lenga P, Gülec G, Bajwa AA, et al. Decompression only versus fusion in octogenarians with spinal epidural abscesses: early complications, clinical and radiological outcome with 2-year follow-up. Neurosurg Rev. 2022 Aug;45(4):2877-85.
https://link.springer.com/article/10.1007/s10143-022-01805-4
http://www.ncbi.nlm.nih.gov/pubmed/35536406?tool=bestpractice.com
[15]Lenga P, Gülec G, Bajwa AA, et al. Surgical management of spinal epidural abscess in elderly patients: a comparative analysis between patients 65-79 years and ≥80 years with 3-year follow-up. World Neurosurg. 2022 Nov;167:e795-805.
http://www.ncbi.nlm.nih.gov/pubmed/36041723?tool=bestpractice.com
Entre adultos mais velhos com idade ≥80 anos com AEE, foram relatadas taxas de mortalidade intra-hospitalar de 5.6% e 11.8%.[14]Lenga P, Gülec G, Bajwa AA, et al. Decompression only versus fusion in octogenarians with spinal epidural abscesses: early complications, clinical and radiological outcome with 2-year follow-up. Neurosurg Rev. 2022 Aug;45(4):2877-85.
https://link.springer.com/article/10.1007/s10143-022-01805-4
http://www.ncbi.nlm.nih.gov/pubmed/35536406?tool=bestpractice.com
[15]Lenga P, Gülec G, Bajwa AA, et al. Surgical management of spinal epidural abscess in elderly patients: a comparative analysis between patients 65-79 years and ≥80 years with 3-year follow-up. World Neurosurg. 2022 Nov;167:e795-805.
http://www.ncbi.nlm.nih.gov/pubmed/36041723?tool=bestpractice.com
Cinco anos após o diagnóstico, um estudo de centro único encontrou uma mortalidade por todas as causas global de 14% entre pacientes com AEE.[16]Chen M, Baumann AN, Fraiman ET, et al. Long-term survivability of surgical and nonsurgical management of spinal epidural abscess. Spine J. 2024 May;24(5):748-58.
https://www.thespinejournalonline.com/article/S1529-9430(24)00002-0/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/38211902?tool=bestpractice.com
A mortalidade ocorre principalmente após sepse ou meningite.