O diagnóstico de pancreatite aguda pode ser estabelecido por meio de uma combinação de critérios clínicos, laboratoriais e de imagem. As ferramentas de escore de gravidade, como APACHE II, Ranson ou Glasgow modificada, são de uso generalizado, mas agregam valor limitado.[8]Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
http://www.ncbi.nlm.nih.gov/pubmed/38857482?tool=bestpractice.com
[52]Zuo L, Wang CH, Yang JL, et al. The role of a workflow in diagnosing biliary causes for acute pancreatitis [in Chinese]. Zhonghua Nei Ke Za Zhi. 2012 Feb;51(2):104-7.
http://www.ncbi.nlm.nih.gov/pubmed/22490809?tool=bestpractice.com
[53]Rompianesi G, Hann A, Komolafe O, et al. Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev. 2017 Apr 21;(4):CD012010.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012010.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/28431198?tool=bestpractice.com
[54]Choosing Wisely. American Society for Clinical Pathology: testing for amylase. Sep 2016 [internet publication].
http://www.choosingwisely.org/clinician-lists/american-society-clinical-pathology-testing-for-amylase
[56]Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas. 2000 May;20(4):367-72.
http://www.ncbi.nlm.nih.gov/pubmed/10824690?tool=bestpractice.com
[68]Capurso G, Ponz de Leon Pisani R, Lauri G, et al. Clinical usefulness of scoring systems to predict severe acute pancreatitis: a systematic review and meta-analysis with pre and post-test probability assessment. United European Gastroenterol J. 2023 Nov;11(9):825-36.
https://www.doi.org/10.1002/ueg2.12464
http://www.ncbi.nlm.nih.gov/pubmed/37755341?tool=bestpractice.com
Em geral, seu uso não é recomendado pelas diretrizes baseadas em evidências.[8]Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
http://www.ncbi.nlm.nih.gov/pubmed/38857482?tool=bestpractice.com
[28]Leppäniemi A, Tolonen M, Tarasconi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019 Jun 13;14:27.
https://wjes.biomedcentral.com/articles/10.1186/s13017-019-0247-0
http://www.ncbi.nlm.nih.gov/pubmed/31210778?tool=bestpractice.com
[47]Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013 Jul-Aug;13(4 Suppl 2):e1-15.
https://www.sciencedirect.com/science/article/pii/S1424390313005255?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/24054878?tool=bestpractice.com
Critérios da International Association of Pancreatology/American Pancreatic Association/American College of Gastroenterology[8]Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
http://www.ncbi.nlm.nih.gov/pubmed/38857482?tool=bestpractice.com
[47]Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013 Jul-Aug;13(4 Suppl 2):e1-15.
https://www.sciencedirect.com/science/article/pii/S1424390313005255?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/24054878?tool=bestpractice.com
Dois de três dos critérios a seguir devem ser atendidos para o diagnóstico de pancreatite aguda:
Clínico (dor na parte superior do abdome)
Laboratoriais (amilase ou lipase sérica >3 o limite superior do normal)
Imagem (tomografia computadorizada [TC], ressonância magnética [RM], ultrassonografia)
Critérios da síndrome da resposta inflamatória sistêmica (SRIS) com fatores de risco da diretriz do American College of Gastroenterology (ACG)[8]Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
http://www.ncbi.nlm.nih.gov/pubmed/38857482?tool=bestpractice.com
[69]Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644-55.
http://www.ncbi.nlm.nih.gov/pubmed/1303622?tool=bestpractice.com
Os critérios de SRIS são usados para a classificação da gravidade, não para o diagnóstico, juntamente com a avaliação de características e fatores de risco adicionais do paciente.
Definição de SRIS atendida pela presença de pelo menos dois dos seguintes critérios:[49]Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003 Apr;31(4):1250-6.
http://www.ncbi.nlm.nih.gov/pubmed/12682500?tool=bestpractice.com
Frequência de pulso >90 batimentos por minuto
Frequência respiratória >20 por minuto ou pressão parcial de dióxido de carbono (PaCO₂) <32 mmHg
Temperatura >38 ºC ou <36 ºC
Contagem leucocitária >12,000 ou <4000 células/mm³, ou >10% de neutrófilos imaturos (bastonetes)
Características e fatores adicionais do paciente identificados pelo ACG como indicativos de pancreatite aguda grave:[8]Tenner S, Vege S, Sheth S, et al. American College of Gastroenterology guidelines: management of acute pancreatitis. Am J Gastroenterol. 2024 Mar 119(3):419-37.
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx
http://www.ncbi.nlm.nih.gov/pubmed/38857482?tool=bestpractice.com
Características do paciente
Achados laboratoriais
Achados radiológicos
Classificação de Atlanta revisada[2]Banks PA, Bollen TL, Dervenis C, et al; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11.
http://gut.bmj.com/content/62/1/102.long
http://www.ncbi.nlm.nih.gov/pubmed/23100216?tool=bestpractice.com
Pancreatite aguda leve
Pancreatite aguda moderadamente grave
Pancreatite aguda grave