Bebês e crianças
A Organização Mundial da Saúde (OMS) recomenda o corte tardio do cordão umbilical para melhorar o estado de ferro e os desfechos de saúde nos neonatos.[43]World Health Organization. Delayed umbilical cord clamping for improved maternal and infant health and nutrition outcomes. 2014 [internet publication].
http://apps.who.int/iris/bitstream/handle/10665/148793/9789241508209_eng.pdf
Ficou comprovado que o corte tardio do cordão umbilical reduz o risco de anemia em neonatos com alto risco de ADF, comparado ao corte precoce.[44]Kc A, Rana N, Målqvist M, et al. Effects of delayed umbilical cord clamping vs early clamping on anemia in infants at 8 and 12 months: a randomized clinical trial. JAMA Pediatr. 2017 Mar 1;171(3):264-70.
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2596270
http://www.ncbi.nlm.nih.gov/pubmed/28114607?tool=bestpractice.com
A OMS também recomenda a suplementação de ferro de rotina em bebês e crianças pequenas que vivem em áreas com grande prevalência de anemia.[45]World Health Organization. Daily iron supplementation in infants and children. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241549523
[Evidência B]fff063e1-3bda-42e2-9ba7-56b1d8f16cc0guidelineBQuais são os efeitos da suplementação oral diária de ferro em comparação com o placebo ou controle em crianças que vivem em ambientes onde a anemia é altamente prevalente?[45]World Health Organization. Daily iron supplementation in infants and children. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241549523
A American Academy of Pediatrics recomenda a suplementação de ferro entre 1 e 12 meses de idade completos para lactentes nascidos <37 semanas de gestação e que são amamentados.[32]Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010 Nov;126(5):1040-50.
https://publications.aap.org/pediatrics/article/126/5/1040/65343/Diagnosis-and-Prevention-of-Iron-Deficiency-and
http://www.ncbi.nlm.nih.gov/pubmed/20923825?tool=bestpractice.com
O uso em longo prazo de suplementação enteral de ferro (≥8 semanas) em prematuros e crianças com baixo peso ao nascer foi associado a um risco reduzido de deficiência de ferro e anemia em uma revisão.[46]McCarthy EK, Dempsey EM, Kiely ME. Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies. Nutr Rev. 2019 Dec 1;77(12):865-77.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888764
http://www.ncbi.nlm.nih.gov/pubmed/31532494?tool=bestpractice.com
Lactentes nascidos a termo que são exclusivamente amamentados devem receber suplementação de ferro dos 4 meses de idade até que os alimentos adequados que contêm ferro tenham sido introduzidos.[32]Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010 Nov;126(5):1040-50.
https://publications.aap.org/pediatrics/article/126/5/1040/65343/Diagnosis-and-Prevention-of-Iron-Deficiency-and
http://www.ncbi.nlm.nih.gov/pubmed/20923825?tool=bestpractice.com
Revisões sistemáticas relatam que o uso de alimentos fortificados com ferro (inclusive fortificação com micronutrientes) e a suplementação de ferro em lactentes e crianças de ensino fundamental (inclusive aquelas de países de renda baixa e média) pode melhorar os desfechos hematológicos e reduzir o risco da deficiência de ferro e anemia.[47]De-Regil LM, Jefferds MED, Peña-Rosas JP. Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age. Cochrane Database Syst Rev. 2017 Nov 23;(11):CD009666.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486284
http://www.ncbi.nlm.nih.gov/pubmed/29168569?tool=bestpractice.com
[48]Das JK, Salam RA, Mahmood SB, et al. Food fortification with multiple micronutrients: impact on health outcomes in general population. Cochrane Database Syst Rev. 2019 Dec 18;(12):CD011400.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917586
http://www.ncbi.nlm.nih.gov/pubmed/31849042?tool=bestpractice.com
[49]Suchdev PS, Jefferds MED, Ota E, et al. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst Rev. 2020 Feb 28;(2):CD008959.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046492
http://www.ncbi.nlm.nih.gov/pubmed/32107773?tool=bestpractice.com
[50]Field MS, Mithra P, Peña-Rosas JP. Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations. Cochrane Database Syst Rev. 2021 Jan 18;(1):CD011302.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011302.pub3/full
http://www.ncbi.nlm.nih.gov/pubmed/33461239?tool=bestpractice.com
[51]Baxter JB, Carducci B, Kamali M, et al. Fortification of salt with iron and iodine versus fortification of salt with iodine alone for improving iron and iodine status. Cochrane Database Syst Rev. 2022 Apr 21;(4):CD013463.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013463.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/35446435?tool=bestpractice.com
[52]da Silva Lopes K, Yamaji N, Rahman MO, et al. Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews. Cochrane Database Syst Rev. 2021 Sep 26;(9):CD013092.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013092.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/34564844?tool=bestpractice.com
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For children from low- and middle-income countries, does point-of-use fortification of foods with micronutrient powders improve outcomes?/cca.html?targetUrl=https://cochranelibrary.com/cca/doi/10.1002/cca.1959/fullMostre-me a resposta
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Can adding multiple micronutrients to food improve health in the general population?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.2954/fullMostre-me a resposta
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How does fortification of salt with iron plus iodine compare with fortification of salt with iodine alone for improving iron and iodine status in children, adolescents, and adults?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.4129/fullMostre-me a resposta
Regiões endêmicas de malária
Há registros de que a suplementação de ferro de rotina em crianças em idade pré-escolar de áreas endêmicas de malária pode aumentar o risco de malária e morte.[5]Pasricha SR, Drakesmith H, Black J, et al. Control of iron deficiency anemia in low- and middle-income countries. Blood. 2013 Apr 4;121(14):2607-17.
http://www.bloodjournal.org/content/121/14/2607.long?sso-checked=true
http://www.ncbi.nlm.nih.gov/pubmed/23355536?tool=bestpractice.com
[53]Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet. 2006 Jan 14;367(9505):133-43.
http://www.ncbi.nlm.nih.gov/pubmed/16413877?tool=bestpractice.com
No entanto, uma revisão Cochrane constatou que a suplementação de ferro, associada aos serviços adequados de prevenção e tratamento da doença, não aumenta o risco clínico de malária em regiões endêmicas.[54]Neuberger A, Okebe J, Yahav D, et al. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst Rev. 2016 Feb 27;(2):CD006589.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006589.pub4/full
http://www.ncbi.nlm.nih.gov/pubmed/26921618?tool=bestpractice.com
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Is there randomized controlled trial evidence to support the use of oral iron supplements (with or without folic acid) in children in malaria-endemic areas?/cca.html?targetUrl=https://cochranelibrary.com/cca/doi/10.1002/cca.1350/fullMostre-me a resposta Caso haja prevalência de malária, a suplementação de ferro deve ser oferecida simultaneamente a medidas de saúde pública para prevenir, diagnosticar e tratar a malária.[45]World Health Organization. Daily iron supplementation in infants and children. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241549523
[55]Cusick SE, Opoka RO, Abrams SA, et al. Delaying iron therapy until 28 days after antimalarial treatment is associated with greater iron incorporation and equivalent hematologic recovery after 56 days in children: a randomized controlled trial. J Nutr. 2016 Sep;146(9):1769-74.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997284
http://www.ncbi.nlm.nih.gov/pubmed/27358418?tool=bestpractice.com
[Evidência A]b97e1ad0-fdb4-491a-99d5-3fb7769d9ecaguidelineAQuais são os efeitos da suplementação oral diária de ferro em comparação com o placebo em bebês e crianças em áreas endêmicas de malária?[45]World Health Organization. Daily iron supplementation in infants and children. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241549523
[
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Is there randomized controlled trial evidence to support the use of oral iron supplements (with or without folic acid) in children in malaria-endemic areas?/cca.html?targetUrl=https://cochranelibrary.com/cca/doi/10.1002/cca.1350/fullMostre-me a resposta
Os efeitos do ferro sobre a malária ainda não estão claros.[56]Moya-Alvarez V, Bodeau-Livinec F, Cot M. Iron and malaria: a dangerous liaison? Nutr Rev. 2016 Oct;74(10):612-23.
http://www.ncbi.nlm.nih.gov/pubmed/27566983?tool=bestpractice.com
Mulheres em idade reprodutiva
A OMS recomenda a suplementação oral de ferro para prevenir a anemia em:[57]World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241549912
[58]World Health Organization. Daily iron supplementation in adult women and adolescent girls. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241510196
[59]World Health Organization. Daily iron supplementation in postpartum women. 2016 [internet publication].
https://apps.who.int/iris/bitstream/handle/10665/249242/9789241549585-eng.pdf?sequence=1&isAllowed=y
Gestantes que vivem em áreas com grande prevalência de anemia na gravidez
Mulheres e garotas menstruadas que vivem em áreas com grande prevalência de anemia[Evidência B]78e4daaf-67b4-4b15-a94d-4bf1b5050913guidelineBQuais são os efeitos da suplementação oral diária de ferro em comparação com o placebo ou controle em mulheres adultas e meninas adolescentes que menstruam?[58]World Health Organization. Daily iron supplementation in adult women and adolescent girls. 2016 [internet publication].
https://www.who.int/publications/i/item/9789241510196
Mulheres no pós-parto que vivem em áreas em que a anemia gestacional é uma questão de saúde pública (a suplementação de ferro deve ser oferecida com ou sem ácido fólico por 6 a 12 semanas após o parto).
Os Centros de Controle e Prevenção de Doenças dos EUA recomendam a suplementação de ferro universal durante a gestação para atender às demandas de ferro elevadas.[8]Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep. 1998 Apr 3;47(RR-3):1-29.
http://www.ncbi.nlm.nih.gov/pubmed/9563847?tool=bestpractice.com
No entanto, a US Preventive Services Task Force (USPSTF) e a British Society for Haematology não encontraram evidências suficientes para recomendar a suplementação de ferro de rotina em gestantes.[60]US Preventive Services Task Force. Iron deficiency anemia in pregnant women: screening and supplementation. Sep 2015 [internet publication].
https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
[61]Pavord S, Daru J, Prasannan N, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020 Mar;188(6):819-30.
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.16221
http://www.ncbi.nlm.nih.gov/pubmed/31578718?tool=bestpractice.com
Revisões sistemáticas relatam que o uso de suplementação de ferro diária por via oral durante a menstruação ou a gestação pode melhorar os desfechos hematológicos e reduzir o risco de deficiência de ferro e anemia.[62]Imdad A, Bhutta ZA. Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes. Paediatr Perinat Epidemiol. 2012 Jul;26(suppl 1):168-77.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3016.2012.01312.x/full
http://www.ncbi.nlm.nih.gov/pubmed/22742609?tool=bestpractice.com
[63]Haider BA, Olofin I, Wang M, et al; Nutrition Impact Model Study Group (anaemia). Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013 Jun 21;346:f3443.
http://www.bmj.com/content/346/bmj.f3443?view=long&pmid=23794316
http://www.ncbi.nlm.nih.gov/pubmed/23794316?tool=bestpractice.com
[64]Low MS, Speedy J, Styles CE, et al. Daily iron supplementation for improving anaemia, iron status and health in menstruating women. Cochrane Database Syst Rev. 2016 Apr 18;(4):CD009747.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009747.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/27087396?tool=bestpractice.com
[65]Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015 Jul 22;(7):CD004736.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004736.pub5/full
http://www.ncbi.nlm.nih.gov/pubmed/26198451?tool=bestpractice.com
[66]Mwangi MN, Prentice AM, Verhoef H. Safety and benefits of antenatal oral iron supplementation in low-income countries: a review. Br J Haematol. 2017 Jun;177(6):884-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485170
http://www.ncbi.nlm.nih.gov/pubmed/28272734?tool=bestpractice.com
[52]da Silva Lopes K, Yamaji N, Rahman MO, et al. Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews. Cochrane Database Syst Rev. 2021 Sep 26;(9):CD013092.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013092.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/34564844?tool=bestpractice.com
A suplementação de ferro intermitente durante a menstruação e a gravidez tem uma eficácia similar à da suplementação diária de ferro, embora a suplementação intermitente na gestação tenha maior probabilidade de resultar em anemia leve em prematuros tardios.[67]Peña-Rosas JP, De-Regil LM, Malave HG, et al. Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015 Oct 19;(10):CD009997.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009997.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/26482110?tool=bestpractice.com
[68]Fernández-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. Cochrane Database Syst Rev. 2019 Jan 31;(1):CD009218.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009218.pub3/full
http://www.ncbi.nlm.nih.gov/pubmed/30699468?tool=bestpractice.com
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How does intermittent compare with daily oral iron supplementation in pregnant women?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.2214/fullMostre-me a resposta
[
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How effective is intermittent iron supplementation for preventing and treating anemia and its associated impairments in menstruating women?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.2590/fullMostre-me a resposta
Uma revisão Cochrane não registrou nenhuma diferença nos desfechos maternos (inclusive anemia materna no terceiro trimestre) com suplementação de múltiplos micronutrientes que contêm ferro durante a gestação, comparada à suplementação de ferro (com ou sem ácido fólico).[69]Keats EC, Haider BA, Tam E, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019 Mar 14;(3):CD004905.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418471
http://www.ncbi.nlm.nih.gov/pubmed/30873598?tool=bestpractice.com
O uso de suplementação de múltiplos micronutrientes pode ser benéfico em países de renda baixa e média, onde as deficiências de micronutrientes são comuns em mulheres em idade reprodutiva.
Foi demonstrado que a suplementação de ferro reduz o risco de anemia em mulheres de baixa renda no pós-parto.[70]Mitra AK, Khoury AJ. Universal iron supplementation: a simple and effective strategy to reduce anaemia among low-income, postpartum women. Public Health Nutr. 2012 Mar;15(3):546-53.
http://journals.cambridge.org/action/displayFulltext?type=6&fid=8480042&jid=PHN&volumeId=15&issueId=03&aid=8480041&bodyId=&membershipNumber=&societyETOCSession=&fulltextType=RA&fileId=S1368980011001261
http://www.ncbi.nlm.nih.gov/pubmed/21729466?tool=bestpractice.com