Com ITU
Oclusões de dutos coletores medulares e nefrolitíase no REM podem causar ITU e pielonefrite.[3]Imam TH, Patail H, Patail H. Medullary sponge kidney: current perspectives. Int J Nephrol Renovasc Dis. 2019;12:213-8.
https://www.dovepress.com/medullary-sponge-kidney-current-perspectives-peer-reviewed-fulltext-article-IJNRD
http://www.ncbi.nlm.nih.gov/pubmed/31576161?tool=bestpractice.com
Esses pacientes precisam de antibióticos. As fluoroquinolonas são adequadas para o tratamento de ITUs complicadas (anormalidades anatômicas e funcionais do trato geniturinário), embora a Food and Drug Administration dos EUA e a European Medicines Agency alertem que as fluoroquinolonas estão associadas a efeitos colaterais incapacitantes e possivelmente permanentes envolvendo tendões, músculos, articulações, nervos e sistema nervoso central.[35]US Food and Drug Administration. FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. 8 March 2018 [internet publication].
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics
[36]European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. 19 March 2019 [internet publication].
https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products
[37]Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. 21 March 2019 [internet publication].
https://www.gov.uk/drug-safety-update/fluoroquinolone-antibiotics-new-restrictions-and-precautions-for-use-due-to-very-rare-reports-of-disabling-and-potentially-long-lasting-or-irreversible-side-effects
Outros antibióticos (por exemplo, sulfametoxazol/trimetoprima, nitrofurantoína) podem ser usados com base nos padrões de resistência locais.[38]Bader MS, Hawboldt J, Brooks A. Management of complicated urinary tract infections in the era of antimicrobial resistance. Postgrad Med. 2010 Nov;122(6):7-15.
http://www.ncbi.nlm.nih.gov/pubmed/21084776?tool=bestpractice.com
A decisão sobre internar o paciente para tratamento com antibiótico intravenoso deve se basear nos sintomas e nas comorbidades do paciente. Consulte Pielonefrite aguda.
A duração recomendada do tratamento é de 14 dias. No entanto, os pacientes com ITU não complicada talvez precisem de apenas um ciclo de 7 dias de antibióticos.
Com nefrolitíase (cálculos renais)
Os pacientes que apresentam cólica renal, nefrolitíase e REM são tratados da mesma maneira que aqueles sem REM.[3]Imam TH, Patail H, Patail H. Medullary sponge kidney: current perspectives. Int J Nephrol Renovasc Dis. 2019;12:213-8.
https://www.dovepress.com/medullary-sponge-kidney-current-perspectives-peer-reviewed-fulltext-article-IJNRD
http://www.ncbi.nlm.nih.gov/pubmed/31576161?tool=bestpractice.com
A prevenção de cálculos recorrentes talvez não seja possível com a anormalidade anatômica do REM. No entanto, os fatores de risco identificados por meio dos perfis de risco para cálculo na urina de 24 horas podem ser usados para orientar a modificação alimentar e a medicação.[3]Imam TH, Patail H, Patail H. Medullary sponge kidney: current perspectives. Int J Nephrol Renovasc Dis. 2019;12:213-8.
https://www.dovepress.com/medullary-sponge-kidney-current-perspectives-peer-reviewed-fulltext-article-IJNRD
http://www.ncbi.nlm.nih.gov/pubmed/31576161?tool=bestpractice.com
[39]Fabris A, Bernich P, Abaterusso C, et al. Bone disease in medullary sponge kidney and effect of potassium citrate treatment. Clin J Am Soc Nephrol. 2009 Dec;4(12):1974-9.
http://www.ncbi.nlm.nih.gov/pubmed/19808216?tool=bestpractice.com
[40]Barcelo P, Wuhl O, Servitge E, et al. Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol. 1993 Dec;150(6):1761-4.
http://www.ncbi.nlm.nih.gov/pubmed/8230497?tool=bestpractice.com
[41]Ettinger B, Tang A, Citron JT, et al. Randomized trial of allopurinol in the prevention of calcium oxalate calculi. N Engl J Med. 1986 Nov 27;315(22):1386-9.
http://www.ncbi.nlm.nih.gov/pubmed/3534570?tool=bestpractice.com
[42]Borghi L, Schianchi T, Meschi T, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002 Jan 10;346(2):77-84.
https://www.nejm.org/doi/full/10.1056/NEJMoa010369
http://www.ncbi.nlm.nih.gov/pubmed/11784873?tool=bestpractice.com
[43]Fabris A, Lupo A, Bernich P, et al. Long-term treatment with potassium citrate and renal stones in medullary sponge kidney. Clin J Am Soc Nephrol. 2010 Sep;5(9):1663-8.
http://www.ncbi.nlm.nih.gov/pubmed/20576821?tool=bestpractice.com
Um estudo retrospectivo mostrou que o citrato de potássio não apenas aumentou o citrato urinário, mas diminuiu a hipercalciúria em pacientes com fatores de risco para cálculos metabólicos, mas os mecanismos não foram esclarecidos.[43]Fabris A, Lupo A, Bernich P, et al. Long-term treatment with potassium citrate and renal stones in medullary sponge kidney. Clin J Am Soc Nephrol. 2010 Sep;5(9):1663-8.
http://www.ncbi.nlm.nih.gov/pubmed/20576821?tool=bestpractice.com
A ingestão de líquidos deve ser aumentada para mais de 2 L/dia para manter o débito urinário alto e reduzir o risco de nefrolitíase e ITU.[44]Borghi L, Meschi T, Amato F, et al. Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol. 1996 Mar;155(3):839-43.
http://www.ncbi.nlm.nih.gov/pubmed/8583588?tool=bestpractice.com
Diuréticos tiazídicos podem ser usados em pacientes com evidência de nefrocalcinose para reduzir a hipercalciúria e a formação de cálculos.[45]Laerum E, Larsen S. Thiazide prophylaxis of urolithiasis: a double-blind study in general practice. Acta Med Scand. 1984;215(4):383-9.
http://www.ncbi.nlm.nih.gov/pubmed/6375276?tool=bestpractice.com
[46]Finkielstein VA, Goldfarb DS. Strategies for preventing calcium oxalate stones. CMAJ. 2006 May 9;174(10):1407-9.
http://www.cmaj.ca/content/174/10/1407.full
http://www.ncbi.nlm.nih.gov/pubmed/16682705?tool=bestpractice.com
O tratamento urológico de cálculos obstrutivos não é revisado aqui. Conforme as práticas endourológicas evoluem, o uso de ureteroscopia e nefrostolitotomia percutânea está suplantando a litotripsia extracorpórea por ondas de choque.[47]Geavlete P, Nita G, Alexandrescu E, et al. The impact of modern endourological techniques in the treatment of a century old disease - medullary sponge kidney with associated nephrolithiasis. J Med Life. 2013;6(4):482-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034299
http://www.ncbi.nlm.nih.gov/pubmed/24868267?tool=bestpractice.com
[48]Sun H, Zhang Z, Yuan J, et al. Safety and efficacy of minimally invasive percutaneous nephrolithotomy in the treatment of patients with medullary sponge kidney. Urolithiasis. 2016 Oct;44(5):421-6.
http://www.ncbi.nlm.nih.gov/pubmed/26671346?tool=bestpractice.com
Consulte Nefrolitíase.