Os linfomas do tecido linfoide associado à mucosa (MALT; também conhecidos como linfoma da zona marginal extranodal do MALT) representam aproximadamente 5% a 8% de todos os linfomas não Hodgkin.[9]Cohen SM, Petryk M, Varma M, et al. Non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue. Oncologist. 2006;11:1100-17.
http://www.ncbi.nlm.nih.gov/pubmed/17110630?tool=bestpractice.com
[10]The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. Blood. 1997;89:3909-3918.
http://bloodjournal.hematologylibrary.org/cgi/content/full/89/11/3909
http://www.ncbi.nlm.nih.gov/pubmed/9166827?tool=bestpractice.com
[11]Zucca E, Bertoni F. The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance. Blood. 2016 Apr 28;127(17):2082-92.
https://www.sciencedirect.com/science/article/pii/S0006497120302172?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/26989205?tool=bestpractice.com
É o tipo mais comum de linfoma da zona marginal (LZM), sendo responsável por aproximadamente 60% de todos os LZMs.[12]Olszewski AJ, Castillo JJ. Survival of patients with marginal zone lymphoma: analysis of the Surveillance, Epidemiology, and End Results database. Cancer. 2013 Feb 1;119(3):629-38.
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.27773
http://www.ncbi.nlm.nih.gov/pubmed/22893605?tool=bestpractice.com
O estômago é o local extranodal mais comumente afetado (linfoma MALT gástrico), sendo responsável por aproximadamente 30% a 40% dos casos.[6]Kiesewetter B, Lamm W, Dolak W, et al. Transformed mucosa-associated lymphoid tissue lymphomas: a single institution retrospective study including polymerase chain reaction-based clonality analysis. Br J Haematol. 2019 Aug;186(3):448-59.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771836
http://www.ncbi.nlm.nih.gov/pubmed/31124124?tool=bestpractice.com
[13]Raderer M, Kiesewetter B, Ferreri AJ. Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). CA Cancer J Clin. 2016 Mar-Apr;66(2):153-71.
https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21330
http://www.ncbi.nlm.nih.gov/pubmed/26773441?tool=bestpractice.com
Os outros sítios comumente afetados incluem os anexos oculares (24%), o pulmão (12%) e as glândulas salivares/parótidas (10%).[6]Kiesewetter B, Lamm W, Dolak W, et al. Transformed mucosa-associated lymphoid tissue lymphomas: a single institution retrospective study including polymerase chain reaction-based clonality analysis. Br J Haematol. 2019 Aug;186(3):448-59.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771836
http://www.ncbi.nlm.nih.gov/pubmed/31124124?tool=bestpractice.com
A pele, o trato intestinal, a tireoide, as mamas, a dura-máter e o trato geniturinário são menos comumente afetados.[7]Kuo SH, Yeh KH, Lin CW, et al. Current status of the spectrum and therapeutics of Helicobacter pylori-negative mucosa-associated lymphoid tissue lymphoma. Cancers (Basel). 2022 Feb 16;14(4):1005.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8869919
http://www.ncbi.nlm.nih.gov/pubmed/35205754?tool=bestpractice.com
Nos EUA, a idade mediana ao diagnóstico de um linfoma MALT é de aproximadamente 67 anos.[12]Olszewski AJ, Castillo JJ. Survival of patients with marginal zone lymphoma: analysis of the Surveillance, Epidemiology, and End Results database. Cancer. 2013 Feb 1;119(3):629-38.
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.27773
http://www.ncbi.nlm.nih.gov/pubmed/22893605?tool=bestpractice.com