Estima-se que a mortalidade decorrente da fasciite necrosante tratada adequadamente com cirurgia e antibióticos esteja entre 10% e 40%. A mortalidade é maior em pacientes que desenvolvem choque e dano de órgão-alvo, chegando a 50% a 70%.[5]Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15;59(2):e10-52.
https://academic.oup.com/cid/article/59/2/e10/2895845
http://www.ncbi.nlm.nih.gov/pubmed/24973422?tool=bestpractice.com
A recorrência de fasciite necrosante é rara.[1]Pasternack MS, Swartz MN. Cellulitis, necrotizing fasciitis, and subcutaneous tissue infections. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. Philadelphia, PA: Elsevier; 2015:1194-215.[5]Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15;59(2):e10-52.
https://academic.oup.com/cid/article/59/2/e10/2895845
http://www.ncbi.nlm.nih.gov/pubmed/24973422?tool=bestpractice.com
No entanto, pode haver morbidade funcional e estética significativa após as terapias cirúrgicas iniciais, o que pode exigir reconstrução subsequente.