Nos EUA, Europa e Japão, a incidência estimada da doença granulomatosa crônica está entre 1 em 200,000 e 1 em 250,000 dos nascidos vivos.[5]Winkelstein JA, Marino MC, Johnston RB Jr., et al. Chronic granulomatous disease: report on a national registry of 368 patients. Medicine (Baltimore). 2000 May;79(3):155-69.
http://www.ncbi.nlm.nih.gov/pubmed/10844935?tool=bestpractice.com
[6]van den Berg JM, van Koppen E, Ahlin A, et al. Chronic granulomatous disease: the European experience. PLoS One. 2009;4(4):e5234.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668749/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/19381301?tool=bestpractice.com
[15]Hasui M. Chronic granulomatous disease in Japan: incidence and natural history. The Study Group of Phagocyte Disorders of Japan. Pediatr Int. 1999 Oct;41(5):589-93.
http://www.ncbi.nlm.nih.gov/pubmed/10530081?tool=bestpractice.com
[16]Rider NL, Jameson MB, Creech CB. Chronic granulomatous disease: epidemiology, pathophysiology, and genetic basis of disease. J Pediatric Infect Dis Soc. 2018 May 9;7(suppl 1):S2-S5.
https://www.doi.org/10.1093/jpids/piy008
http://www.ncbi.nlm.nih.gov/pubmed/29746675?tool=bestpractice.com
Um registro no Reino Unido indicou uma prevalência de 8.5 por milhão para os anos de 1980 a 1989 e 7.5 por milhão de 1990 a 1999.[17]Jones LB, McGrogan P, Flood TJ, et al. Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry. Clin Exp Immunol. 2008 May;152(2):211-8.
https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2008.03644.x/full
http://www.ncbi.nlm.nih.gov/pubmed/18410635?tool=bestpractice.com
Os homens são predominantemente afetados, pois a maioria dos casos está ligada ao cromossomo X (aproximadamente 65% a 70% dos casos).[5]Winkelstein JA, Marino MC, Johnston RB Jr., et al. Chronic granulomatous disease: report on a national registry of 368 patients. Medicine (Baltimore). 2000 May;79(3):155-69.
http://www.ncbi.nlm.nih.gov/pubmed/10844935?tool=bestpractice.com
[6]van den Berg JM, van Koppen E, Ahlin A, et al. Chronic granulomatous disease: the European experience. PLoS One. 2009;4(4):e5234.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668749/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/19381301?tool=bestpractice.com
[18]Mouy R, Veber F, Blanche S, et al. Long-term itraconazole prophylaxis against Aspergillus infections in thirty-two patients with chronic granulomatous disease. J Pediatr. 1994 Dec;125(6 Pt 1):998-1003.
http://www.ncbi.nlm.nih.gov/pubmed/7996377?tool=bestpractice.com
[19]Martire B, Rondelli R, Soresina A, et al. Clinical features, long-term follow-up and outcome of a large cohort of patients with chronic granulomatous disease: an Italian multicenter study. Clin Immunol. 2008 Feb;126(2):155-64.
http://www.ncbi.nlm.nih.gov/pubmed/18037347?tool=bestpractice.com
Praticamente 40% dos pacientes nos EUA são diagnosticados antes de 1 ano de idade; a maioria dos pacientes é diagnosticada aos 5 anos de idade.[5]Winkelstein JA, Marino MC, Johnston RB Jr., et al. Chronic granulomatous disease: report on a national registry of 368 patients. Medicine (Baltimore). 2000 May;79(3):155-69.
http://www.ncbi.nlm.nih.gov/pubmed/10844935?tool=bestpractice.com
No Reino Unido, a idade mediana de diagnóstico é de 2.7 anos.[17]Jones LB, McGrogan P, Flood TJ, et al. Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry. Clin Exp Immunol. 2008 May;152(2):211-8.
https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2008.03644.x/full
http://www.ncbi.nlm.nih.gov/pubmed/18410635?tool=bestpractice.com
A condição pode permanecer não diagnosticada até a idade adulta, com a maioria dos diagnósticos tardios apresentando formas autossômicas recessivas da doença.[5]Winkelstein JA, Marino MC, Johnston RB Jr., et al. Chronic granulomatous disease: report on a national registry of 368 patients. Medicine (Baltimore). 2000 May;79(3):155-69.
http://www.ncbi.nlm.nih.gov/pubmed/10844935?tool=bestpractice.com
[6]van den Berg JM, van Koppen E, Ahlin A, et al. Chronic granulomatous disease: the European experience. PLoS One. 2009;4(4):e5234.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668749/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/19381301?tool=bestpractice.com
A United States Immunodeficiency Network (USIDNET) conta com um registro on-line de pacientes com doenças de imunodeficiência primária, inclusive doença granulomatosa crônica.
The United States Immunodeficiency Network
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