Os pacientes devem ser aconselhados a usar protetor solar e roupas e dispositivos de proteção, ou a ficar longe do sol.[44]National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer [internet publication].
https://www.nccn.org/guidelines/category_1
[100]Sánchez G, Nova J, Rodriguez-Hernandez AE, et al. Sun protection for preventing basal cell and squamous cell skin cancers. Cochrane Database Syst Rev. 2016 Jul 25;(7):CD011161.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011161.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/27455163?tool=bestpractice.com
No entanto, o dano solar é suficientemente avançado na maioria dos casos, de forma que isso não evitará o surgimento de novos carcinomas basocelulares (CBCs).
A detecção e a remoção precoces previnem complicações adicionais de maneira efetiva.[101]Berking C. Photocarcinogenesis: molecular mechanisms and preventive strategies. Hautarzt. 2007 May;58(5):398-405.
http://www.ncbi.nlm.nih.gov/pubmed/17429584?tool=bestpractice.com
A quimioprevenção utilizando nicotinamida ou capecitabina oral pode ser benéfica para os pacientes de alto risco.[102]Chen AC, Martin AJ, Choy B, et al. A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. N Engl J Med. 2015 Oct 22;373(17):1618-26.
https://www.nejm.org/doi/10.1056/NEJMoa1506197
http://www.ncbi.nlm.nih.gov/pubmed/26488693?tool=bestpractice.com
[103]Schauder DM, Kim J, Nijhawan RI. Evaluation of the use of capecitabine for the treatment and prevention of actinic keratoses, squamous cell carcinoma, and basal cell carcinoma: a systematic review. JAMA Dermatol. 2020 Oct 1;156(10):1117-24.
http://www.ncbi.nlm.nih.gov/pubmed/32639538?tool=bestpractice.com
Um inibidor da via hedgehog pode ser usado no tratamento da síndrome do nevo basocelular para reduzir a carga tumoral e nova ocorrência de CBC.[60]Tang JY, Mackay-Wiggan JM, Aszterbaum M, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med. 2012 Jun 7;366(23):2180-8.
http://www.ncbi.nlm.nih.gov/pubmed/22670904?tool=bestpractice.com