A leptospirose é a infecção zoonótica mais disseminada no mundo. Estima-se que o número anual de casos seja de 1.03 milhão, com aproximadamente 60,000 mortes.[21]Costa F, Hagan JE, Calcagno J, et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis. 2015;9(9):e0003898.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003898
http://www.ncbi.nlm.nih.gov/pubmed/26379143?tool=bestpractice.com
Aproximadamente, 100-200 casos são identificados por ano nos EUA, com cerca de 50% dos casos relatados em Porto Rico; o Havaí tem a segunda maior incidência.[22]Centers for Disease Control and Prevention. Healthcare workers: technical information for leptospirosis. Apr 2021 [internet publication].
https://www.cdc.gov/leptospirosis/health_care_workers/index.html
As infecções e surtos ocorrem em áreas rurais e urbanas nas regiões tropicais, subtropicais e temperadas.[23]Torgerson PR, Hagan JE, Costa F, et al. Global burden of leptospirosis: estimated in terms of disability adjusted life years. PLoS Negl Trop Dis. 2015;9(10):e0004122.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004122
http://www.ncbi.nlm.nih.gov/pubmed/26431366?tool=bestpractice.com
[24]Munoz-Zanzi C, Groene E, Morawski BM, et al. A systematic literature review of leptospirosis outbreaks worldwide, 1970-2012. Rev Panam Salud Publica. 2020;44:e78.
https://iris.paho.org/bitstream/handle/10665.2/52466/v44e782020.pdf?sequence=1&isAllowed=y
http://www.ncbi.nlm.nih.gov/pubmed/32684917?tool=bestpractice.com
A incidência atinge sua intensidade máxima durante a estação das chuvas, em áreas tropicais, e durante o final do verão, em regiões temperadas.[1]Levett P. Leptospirosis. In: Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 6th ed. Philadelphia, PA: Churchill Livingstone; 2006:2495-500.[7]Desai S, Van Treeck U, Lierz M, et al. Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007. Clin Infect Dis. 2009 Mar 15;48(6):691-7.
https://academic.oup.com/cid/article/48/6/691/284295
http://www.ncbi.nlm.nih.gov/pubmed/19193108?tool=bestpractice.com
Normalmente, os surtos estão associados com atividades de trabalho ao ar livre, exposição à água de enchentes e contato com água contaminada.[24]Munoz-Zanzi C, Groene E, Morawski BM, et al. A systematic literature review of leptospirosis outbreaks worldwide, 1970-2012. Rev Panam Salud Publica. 2020;44:e78.
https://iris.paho.org/bitstream/handle/10665.2/52466/v44e782020.pdf?sequence=1&isAllowed=y
http://www.ncbi.nlm.nih.gov/pubmed/32684917?tool=bestpractice.com
É provável que os surtos de leptospirose associados a enchentes continuem a aumentar devido a eventos climáticos extremos e às mudanças climáticas.[25]Lau CL, Smythe LD, Craig SB, et al. Climate change, flooding, urbanisation and leptospirosis: fuelling the fire? Trans R Soc Trop Med Hyg. 2010 Oct;104(10):631-8.
http://www.ncbi.nlm.nih.gov/pubmed/20813388?tool=bestpractice.com
[26]Chadsuthi S, Chalvet-Monfray K, Wiratsudakul A, et al. The effects of flooding and weather conditions on leptospirosis transmission in Thailand. Sci Rep. 2021 Jan 15;11(1):1486.
https://www.nature.com/articles/s41598-020-79546-x
http://www.ncbi.nlm.nih.gov/pubmed/33452273?tool=bestpractice.com
O principal fator de risco da leptospirose é o contato direto ou indireto com a urina de animais infectados. O contato pode ocorrer como resultado da exposição ocupacional ou por meio do contato com água ou solo contaminado com leptospiras. Portanto, os grupos com alto risco de infecção incluem agricultores de subsistência rural, habitantes de favelas urbanas, veterinários, pessoas que manuseiam animais, militares e mineradores.[21]Costa F, Hagan JE, Calcagno J, et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis. 2015;9(9):e0003898.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003898
http://www.ncbi.nlm.nih.gov/pubmed/26379143?tool=bestpractice.com
[27]Barragan V, Olivas S, Keim P, et al. Critical knowledge gaps in our understanding of environmental cycling and transmission of Leptospira spp. Appl Environ Microbiol. 2017 Oct 1;83(19):e01190-17.
https://journals.asm.org/doi/10.1128/AEM.01190-17
http://www.ncbi.nlm.nih.gov/pubmed/28754706?tool=bestpractice.com
Trabalhadores e atletas que participam de esportes aquáticos representam uma população em crescente risco de infecção: nadar, praticar rafting, caiaque, canoagem, pesca, caça e trilha de bicicleta em água doce estão associados a infecções de leptospirose, sobretudo após fortes pancadas de chuvas e enchentes.[28]Stern EJ, Galloway R, Shadomy SV, et al. Outbreak of leptospirosis among Adventure Race participants in Florida, 2005. Clin Infect Dis. 2010 Mar 15;50(6):843-9.
https://academic.oup.com/cid/article/50/6/843/418018
http://www.ncbi.nlm.nih.gov/pubmed/20146629?tool=bestpractice.com
[29]Morgan J, Bornstein SL, Karpati AM, et al. Outbreak of leptospirosis among triathlon participants in community residents in Springfield, Illinois, 1998. Clin Infect Dis. 2002 Jun 15;34(12):1593-9.
https://academic.oup.com/cid/article/34/12/1593/348795
http://www.ncbi.nlm.nih.gov/pubmed/12032894?tool=bestpractice.com
[30]Centers for Disease Control and Prevention (CDC). Outbreak of leptospirosis among white-water rafters - Costa Rica, 1996. MMWR Morb Mortal Wkly Rep. 1997 Jun 27;46(25):577-9.
https://www.cdc.gov/mmwr/preview/mmwrhtml/00048052.htm
http://www.ncbi.nlm.nih.gov/pubmed/9214567?tool=bestpractice.com
[31]Sejvar J, Bancroft E, Winthrop K, et al; Eco-Challenge Investigation Team. Leptospirosis in "Eco-Challenge" athletes, Malaysian Borneo, 2000. Emerg Infect Dis. 2003 Jun;9(6):702-7.
https://wwwnc.cdc.gov/eid/article/9/6/02-0751_article
http://www.ncbi.nlm.nih.gov/pubmed/12781010?tool=bestpractice.com
[32]Lau C, Smythe L, Weinstein P. Leptospirosis: an emerging disease in travellers Travel Med Infect Dis. 2010 Jan;8(1):33-9.
http://www.ncbi.nlm.nih.gov/pubmed/20188303?tool=bestpractice.com
De maneira incomum, ocorreram infecções após acidentes laboratoriais, transfusão sanguínea e transplantes cirúrgicos.[33]Ansdell VE. Leptospirosis. In: John EC, Mc Mullen R. The travel and tropical medicine manual. 2nd ed. Philadelphia, PA: Saunders; 2003:335-44. A transmissão de um humano para outro humano é muito rara.[34]Levett PN. Leptospirosis. Clin Microbiol Rev. 2001 Apr;14(2):296-326.
https://journals.asm.org/doi/10.1128/CMR.14.2.296-326.2001
http://www.ncbi.nlm.nih.gov/pubmed/11292640?tool=bestpractice.com
A infecção pode ser adquirida por andar descalço durante atividades da vida diária.[35]Yusti D, Arboleda M, Agudelo-Flórez P. Social and environmental risk factors associated with leptospirosis of inpatient and outpatient management, Turbo, Colombia [in Spanish]. Biomedica. 2013 Sep;33 Suppl 1:117-29.
http://www.ncbi.nlm.nih.gov/pubmed/24652256?tool=bestpractice.com
[36]Mwachui MA, Crump L, Hartskeerl R, et al. Environmental and behavioural determinants of leptospirosis transmission: a systematic review. PLoS Negl Trop Dis. 2015;9(9):e0003843.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003843
http://www.ncbi.nlm.nih.gov/pubmed/26379035?tool=bestpractice.com
Outros fatores de risco para leptospirose incluem condições de vida desfavoráveis, como assoalho sujo, proximidade de esgoto e esgoto a céu aberto e falta de saneamento.[36]Mwachui MA, Crump L, Hartskeerl R, et al. Environmental and behavioural determinants of leptospirosis transmission: a systematic review. PLoS Negl Trop Dis. 2015;9(9):e0003843.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003843
http://www.ncbi.nlm.nih.gov/pubmed/26379035?tool=bestpractice.com
A incidência de leptospirose é maior entre homens, mas, provavelmente, isso é resultado de um viés relacionado à exposição, pois os surtos associados com eventos atléticos resultaram em taxas de infecção similares em homens e mulheres.[29]Morgan J, Bornstein SL, Karpati AM, et al. Outbreak of leptospirosis among triathlon participants in community residents in Springfield, Illinois, 1998. Clin Infect Dis. 2002 Jun 15;34(12):1593-9.
https://academic.oup.com/cid/article/34/12/1593/348795
http://www.ncbi.nlm.nih.gov/pubmed/12032894?tool=bestpractice.com
[31]Sejvar J, Bancroft E, Winthrop K, et al; Eco-Challenge Investigation Team. Leptospirosis in "Eco-Challenge" athletes, Malaysian Borneo, 2000. Emerg Infect Dis. 2003 Jun;9(6):702-7.
https://wwwnc.cdc.gov/eid/article/9/6/02-0751_article
http://www.ncbi.nlm.nih.gov/pubmed/12781010?tool=bestpractice.com
A literatura relata que as doenças graves podem ser mais comuns em homens que em mulheres.[37]Skufca J, Arima Y. Sex, gender and emerging infectious disease surveillance: a leptospirosis case study. Western Pac Surveill Response J. 2012 Jul;3(3):37-9.
https://ojs.wpro.who.int/ojs/index.php/wpsar/article/view/156
http://www.ncbi.nlm.nih.gov/pubmed/23908921?tool=bestpractice.com
Não foi observada nenhuma predominância em qualquer faixa etária.
Os médicos devem estar cientes de que podem ocorrer coinfecções com a leptospirose, inclusive dengue, malária, rickettsia, tifo esfoliante e HIV.[14]Md-Lasim A, Mohd-Taib FS, Abdul-Halim M, et al. Leptospirosis and coinfection: should we be concerned? Int J Environ Res Public Health. 2021 Sep 6;18(17):9411.
https://www.mdpi.com/1660-4601/18/17/9411/htm
http://www.ncbi.nlm.nih.gov/pubmed/34502012?tool=bestpractice.com
[15]Dhanashree B, Shenoy S. Seropositivity for dengue and Leptospira IgM among patients with acute febrile illness: an indicator of co-infection? Germs. 2021 Jun;11(2):155-62.
http://www.germs.ro/en/Articles/Seropositivity-for-dengue-and-Leptospira-IgM-among-patients-with-acute-febrile-illness-an-indicator-of-co-infection--1392
http://www.ncbi.nlm.nih.gov/pubmed/34422688?tool=bestpractice.com
[16]Wilairatana P, Mala W, Rattaprasert P, et al. Prevalence of malaria and leptospirosis co-infection among febrile patients: a systematic review and meta-analysis. Trop Med Infect Dis. 2021 Jul 3;6(3):122.
https://www.mdpi.com/2414-6366/6/3/122/htm
http://www.ncbi.nlm.nih.gov/pubmed/34287366?tool=bestpractice.com
[17]Mehta V, Bhasi A, Panda PK, et al. A coinfection of severe leptospirosis and scrub typhus in Indian Himalayas. J Family Med Prim Care. 2019 Oct;8(10):3416-8.
https://journals.lww.com/jfmpc/Fulltext/2019/08100/A_coinfection_of_severe_leptospirosis_and_scrub.59.aspx
http://www.ncbi.nlm.nih.gov/pubmed/31742180?tool=bestpractice.com
[18]Biggs HM, Galloway RL, Bui DM, et al. Leptospirosis and human immunodeficiency virus co-infection among febrile inpatients in northern Tanzania. Vector Borne Zoonotic Dis. 2013 Aug;13(8):572-80.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741414
http://www.ncbi.nlm.nih.gov/pubmed/23663165?tool=bestpractice.com