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Last reviewed: 21 Mar 2025
Last updated: 26 Nov 2024

Summary

Definition

History and exam

Key diagnostic factors

  • advanced age
  • ethnicity
  • previous osteoporotic vertebral compression fracture
  • acute back pain
  • asymptomatic

Other diagnostic factors

  • history of long-term corticosteroid use
  • bone-losing medications
  • kyphotic deformity
  • loss of lumbar lordosis
  • localised tenderness
  • loss of standing height
  • loss of sagittal balance

Risk factors

  • older age
  • previous osteoporotic vertebral compression fracture
  • low body weight
  • recent weight loss
  • family history of low bone mass/osteoporotic fractures
  • smoking
  • white or Asian race
  • postmenopausal status
  • secondary amenorrhoea
  • alcohol (>2 units/day)
  • corticosteroid use
  • glucocorticoid excess
  • hyperthyroidism
  • vitamin D deficiency
  • low calcium intake
  • rheumatoid arthritis and other autoimmune connective tissue diseases
  • endocrine disorders (e.g., hypogonadism, hyperparathyroidism, hyperprolactinaemia, acromegaly, hypercortisolism, hyperthyroidism)
  • gastrointestinal diseases (e.g., inflammatory bowel disease, coeliac disease, malabsorption syndromes, post-bariatric surgery)
  • liver diseases (e.g., biliary sclerosis, sclerosing cholangitis, alcoholic cirrhosis, autoimmune hepatitis)
  • dietary disorders (e.g., anorexia nervosa/bulimia, inadequate diet, total parenteral nutrition)
  • neurological disorders (e.g., stroke, multiple sclerosis, Parkinson's disease, spinal cord injury, long-term immobilisation)
  • renal disease
  • type 1 diabetes mellitus
  • organ transplantation
  • bone-losing medications

Diagnostic investigations

Investigations to consider

  • CT spine
  • MRI spine
  • technetium-99m (Tc-99m) whole-body bone scan (bone scintigraphy)
  • single-photon emission computed tomography (SPECT)/CT
  • bone densitometry scan
  • CT myelogram
  • FBC
  • bone profile (including serum calcium and alkaline phosphatase)
  • C-reactive protein
  • blood cultures

Treatment algorithm

Contributors

Authors

Nasir A. Quraishi, LLM, FRCS

Consultant Spine Surgeon & Honorary Clinical Associate Professor

Centre for Spinal Studies and Surgery

Queen’s Medical Centre

Nottingham

UK

Disclosures

NAQ declares that he has no competing interests.

Opinder Sahota, FRCP, DM, FHEA

Professor of Orthogeriatric Medicine & Consultant Physician

Queen's Medical Centre

Nottingham University Hospitals NHS Trust

Nottingham

UK

Disclosures

OS declares that he has no competing interests.

Acknowledgements

Dr Nasir A. Quraishi and Dr Opinder Sahota would like to gratefully acknowledge Dr Jeremy Fairbank, previous contributor to this topic.

Peer reviewers

Kee D. Kim, MD

Professor of Neurological Surgery

University of California

Davis

CA

Disclosures

KDK declares that he has no competing interests.

Micky Malhotra, MBBS, DTCD, MD, MRCP

Consultant Physician

Wrightington, Wigan & Leigh NHS Foundation Trust

Wigan

UK

Disclosures

MM declares that he has no competing interests.

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