Prognosis

​Patients with Brugada syndrome (BrS) who have genetic mutations of SCN5A tend to develop symptoms at a younger age, and have more pronounced electrophysiological defects (e.g., higher rate of spontaneous type 1 ECG pattern, significant conduction or repolarisation abnormalities, increased atrial vulnerability) and a more severe prognosis.[92]

Age ≥55 at diagnosis is associated with a more benign prognosis, with no increased mortality compared with the general population.[1]

Established features that are associated with the greatest risk of serious arrhythmic events in patients with BrS are:[1][40][86][87][88]

  • Resuscitated cardiac arrest

  • History of cardiogenic syncope

  • Spontaneous type 1 Brugada pattern on ECG.

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