Stroke may be the initial presentation of atrial fibrillation (AF). Studies evaluating patients with a first-ever ischaemic stroke have found the prevalence of AF to be 15% to 25%.[4]Marini C, De Santis F, Sacco S, et al. Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke. 2005 Jun;36(6):1115-9.
https://www.ahajournals.org/doi/full/10.1161/01.STR.0000166053.83476.4a
http://www.ncbi.nlm.nih.gov/pubmed/15879330?tool=bestpractice.com
[5]Paciaroni M, Agnelli G, Caso V, et al. Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event and effect on clinical outcome. J Thromb Haemost. 2005 Jun;3(6):1218-23.
http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2005.01344.x/full
http://www.ncbi.nlm.nih.gov/pubmed/15892862?tool=bestpractice.com
Furthermore, studies assessing prolonged ECG monitoring (using a 30-day event-triggered recorder or an insertable cardiac monitoring device) in patients with cryptogenic stroke have found AF to be common in these patients.[94]Gladstone DJ, Spring M, Dorian P, et al. Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med. 2014 Jun 26;370(26):2467-77.
https://www.nejm.org/doi/10.1056/NEJMoa1311376
http://www.ncbi.nlm.nih.gov/pubmed/24963566?tool=bestpractice.com
[95]Sanna T, Diener HC, Passman RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014 Jun 26;370(26):2478-86.
https://www.nejm.org/doi/10.1056/NEJMoa1313600
http://www.ncbi.nlm.nih.gov/pubmed/24963567?tool=bestpractice.com
Therefore, strategies for primary preventative screening for AF in patients at high risk of stroke can be considered. The US Preventive Services Task Force advises that current evidence is insufficient to assess the balance of benefits and harms of screening for AF.[96]US Preventive Services Task Force. Final recommendation statement. Atrial fibrillation: screening. 25 January 2022 [internet publication].
https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/atrial-fibrillation-screening
There is no expert consensus or guideline recommendation on screening patients with asymptomatic AF. However, screening for AF can be performed in patients implanted with a pacemaker or defibrillator. In an observational study involving patients receiving an implantable pacemaker, new-onset AF and long-term AF burden were frequently observed in patients with heart block or sinus node disease, but were significantly more predominant in patients with sinus node disease in whom AF is part of the syndrome.[97]Gillis AM, Morck M. Atrial fibrillation after DDDR pacemaker implantation. J Cardiovasc Electrophysiol. 2002 Jun;13(6):542-7.
http://www.ncbi.nlm.nih.gov/pubmed/12108493?tool=bestpractice.com
Patients undergoing cancer treatment are at higher risk of AF, and should have an ECG as part of a baseline cardiovascular risk assessment.[61]Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022 Nov 1;43(41):4229-361.
https://www.doi.org/10.1093/eurheartj/ehac244
http://www.ncbi.nlm.nih.gov/pubmed/36017568?tool=bestpractice.com
Those at higher risk, for example those on certain chemotherapy agents, should be screened with more regular ECGs and/or opportunistic pulse taking.[61]Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022 Nov 1;43(41):4229-361.
https://www.doi.org/10.1093/eurheartj/ehac244
http://www.ncbi.nlm.nih.gov/pubmed/36017568?tool=bestpractice.com
Mobile health technologies, including smart devices, have become a popular research area for AF detection.[87]Lopez Perales CR, Van Spall HGC, Maeda S, et al. Mobile health applications for the detection of atrial fibrillation: a systematic review. Europace. 2021 Jan 27;23(1):11-28.
https://www.doi.org/10.1093/europace/euaa139
http://www.ncbi.nlm.nih.gov/pubmed/33043358?tool=bestpractice.com
[88]Guo Y, Wang H, Zhang H, et al. Mobile Photoplethysmographic Technology to Detect Atrial Fibrillation. J Am Coll Cardiol. 2019 Nov 12;74(19):2365-2375.
https://www.doi.org/10.1016/j.jacc.2019.08.019
http://www.ncbi.nlm.nih.gov/pubmed/31487545?tool=bestpractice.com
A large number of mobile health apps and wearable activity monitors are available, but many are not clinically validated and caution is advised for clinical use.[1]Joglar JA, Chung MK, Armbruster AL, et al. 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2024 Jan 2;149(1):e1-156.
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001193?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
http://www.ncbi.nlm.nih.gov/pubmed/38033089?tool=bestpractice.com
[2]Hindricks G, Potpara T, Dagres N, et al. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021 Feb 1;42(5):373-498.
https://academic.oup.com/eurheartj/article/42/5/373/5899003
http://www.ncbi.nlm.nih.gov/pubmed/32860505?tool=bestpractice.com
If AF is detected by mobile or wearable devices, diagnosis should be confirmed with single-lead or 12-lead ECG analysed by a physician with expertise in ECG rhythm interpretation.[1]Joglar JA, Chung MK, Armbruster AL, et al. 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2024 Jan 2;149(1):e1-156.
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001193?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
http://www.ncbi.nlm.nih.gov/pubmed/38033089?tool=bestpractice.com
[2]Hindricks G, Potpara T, Dagres N, et al. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021 Feb 1;42(5):373-498.
https://academic.oup.com/eurheartj/article/42/5/373/5899003
http://www.ncbi.nlm.nih.gov/pubmed/32860505?tool=bestpractice.com