A actinomicose geralmente é diagnosticada após uma cirurgia para tratamento de um abscesso ou tumor. É necessário o tratamento sistêmico prolongado com antibióticos em alta dosagem, às vezes juntamente com a cirurgia.[48]Wagenlehner FM, Mohren B, Naber KG, et al. Abdominal actinomycosis. Clin Microbiol Infect. 2003 Aug;9(8):881-5.
http://onlinelibrary.wiley.com/doi/10.1046/j.1469-0691.2003.00653.x/full
http://www.ncbi.nlm.nih.gov/pubmed/14616714?tool=bestpractice.com
[49]Martin MV. The use of oral amoxycillin for the treatment of actinomycosis: a clinical and in vitro study. Br Dent J. 1984 Apr 7;156(7):252-4.
http://www.ncbi.nlm.nih.gov/pubmed/6584159?tool=bestpractice.com
[50]Spilsbury BW, Johnstone FR. The clinical course of actinomycotic infections: a report of 14 cases. Can J Surg. 1962 Jan;5:33-48.
http://www.ncbi.nlm.nih.gov/pubmed/13915786?tool=bestpractice.com
[51]Sudhakar SS, Ross JJ. Short-term treatment of actinomycosis: two cases and a review. Clin Infect Dis. 2004 Feb 1;38(3):444-7.
http://cid.oxfordjournals.org/content/38/3/444.long
http://www.ncbi.nlm.nih.gov/pubmed/14727221?tool=bestpractice.com
[52]Nielsen PM, Novak A. Acute cervico-facial actinomycosis. Int J Oral Maxillofac Surg. 1987 Aug;16(4):440-4.
http://www.ncbi.nlm.nih.gov/pubmed/3117916?tool=bestpractice.com
[53]Martin MV. Antibiotic treatment of cervicofacial actinomycosis for patients allergic to penicillin: a clinical and in vitro study. Br J Oral Maxillofac Surg. 1985 Dec;23(6):428-34.
http://www.ncbi.nlm.nih.gov/pubmed/2933063?tool=bestpractice.com
[54]Leafstedt SW, Gleeson RM. Cervicofacial actinomycosis. Am J Surg. 1975 Oct;130(4):496-8.
http://www.ncbi.nlm.nih.gov/pubmed/1166943?tool=bestpractice.com
Com essa abordagem, o desfecho é favorável em mais de 90% dos casos.[1]Smego RA Jr, Foglia G. Actinomycosis. Clin Infect Dis. 1998 Jun;26(6):1255-61.
http://www.ncbi.nlm.nih.gov/pubmed/9636842?tool=bestpractice.com
A recidiva é rara após tratamento suficiente com antibióticos. Caso ocorra, é tratada da mesma forma que uma infecção primária.
Manejo e tratamento com antibióticos
Penicilina em alta dose é a opção preferida, administrada por via intravenosa durante 4 a 6 semanas, seguida por terapia oral durante mais 3 a 6 meses. A terapia intravenosa pode ser administrada a um paciente hospitalizado ou ambulatorial, dependendo da gravidade da doença.[1]Smego RA Jr, Foglia G. Actinomycosis. Clin Infect Dis. 1998 Jun;26(6):1255-61.
http://www.ncbi.nlm.nih.gov/pubmed/9636842?tool=bestpractice.com
[11]Russo T. Actinomycosis. In: Kasper DL, Fauci AS, Longo DL, et al, eds. Harrison's principles of internal medicine. 16th ed. New York, NY: McGraw-Hill; 2005:937-9.[51]Sudhakar SS, Ross JJ. Short-term treatment of actinomycosis: two cases and a review. Clin Infect Dis. 2004 Feb 1;38(3):444-7.
http://cid.oxfordjournals.org/content/38/3/444.long
http://www.ncbi.nlm.nih.gov/pubmed/14727221?tool=bestpractice.com
Para pacientes alérgicos à penicilina, pode-se usar ceftriaxona, clindamicina, eritromicina ou doxiciclina parenteral.[48]Wagenlehner FM, Mohren B, Naber KG, et al. Abdominal actinomycosis. Clin Microbiol Infect. 2003 Aug;9(8):881-5.
http://onlinelibrary.wiley.com/doi/10.1046/j.1469-0691.2003.00653.x/full
http://www.ncbi.nlm.nih.gov/pubmed/14616714?tool=bestpractice.com
[53]Martin MV. Antibiotic treatment of cervicofacial actinomycosis for patients allergic to penicillin: a clinical and in vitro study. Br J Oral Maxillofac Surg. 1985 Dec;23(6):428-34.
http://www.ncbi.nlm.nih.gov/pubmed/2933063?tool=bestpractice.com
[54]Leafstedt SW, Gleeson RM. Cervicofacial actinomycosis. Am J Surg. 1975 Oct;130(4):496-8.
http://www.ncbi.nlm.nih.gov/pubmed/1166943?tool=bestpractice.com
[55]Makaryus AN, Latzman J, Yang R, et al. A rare case of Actinomyces israelii presenting as pericarditis in a 75-year-old man. Cardiol Rev. 2005 May-Jun;13(3):125-7.
http://www.ncbi.nlm.nih.gov/pubmed/15831144?tool=bestpractice.com
[56]Brown R, Bancewicz J. Ureteric obstruction due to pelvic actinomycosis. Br J Surg. 1982 Mar;69(3):156.
http://www.ncbi.nlm.nih.gov/pubmed/7066656?tool=bestpractice.com
Pacientes com actinomicose cérvico-facial leve de origem endodôntica podem receber doxiciclina oral desde o início.
Recomenda-se a consulta com um especialista em microbiologia ou em doenças infecciosas.[7]Wong VK, Turmezei TD, Weston VC. Actinomycosis. BMJ. 2011 Oct 11;343:d6099.
http://www.ncbi.nlm.nih.gov/pubmed/21990282?tool=bestpractice.com
Os dispositivos intrauterinos devem ser removidos das pacientes com actinomicose pélvica ou abdominal.[7]Wong VK, Turmezei TD, Weston VC. Actinomycosis. BMJ. 2011 Oct 11;343:d6099.
http://www.ncbi.nlm.nih.gov/pubmed/21990282?tool=bestpractice.com
[57]Bonacho I, Pita S, Gómez-Besteiro MI. The importance of the removal of the intrauterine device in genital colonization by actinomyces. Gynecol Obstet Invest. 2001;52(2):119-23.
http://www.ncbi.nlm.nih.gov/pubmed/11586040?tool=bestpractice.com