Emerging treatments
Isavuconazonium
Isavuconazonium (a prodrug of isavuconazole), an extended-spectrum triazole antifungal, has shown activity against Histoplasma capsulatum, although there are insufficient data available to recommend its routine use in the treatment of histoplasmosis.[63]
Corticosteroids
Anecdotal reports suggest that the addition of methylprednisolone during the first 2 weeks of antifungal therapy in patients who develop respiratory complications, including hypoxemia or significant respiratory distress, may lead to clinical improvement, although clinical trials are lacking.[64]
Use of this content is subject to our disclaimer