The most commonly used diagnostic test for aspiration is the bedside swallow evaluation. This test includes a patient interview, a physical exam, and the assessment for signs of aspiration. While this is usually performed by a speech-language pathologist, to streamline the diagnostic evaluation some of the more sensitive components of the bedside swallow evaluation can be performed individually or in combination as screening tests.[88]Brodsky MB, Suiter DM, González-Fernández M, et al. Screening accuracy for aspiration using bedside water swallow tests: a systematic review and meta-analysis. Chest. 2016 Jul;150(1):148-63.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980548
http://www.ncbi.nlm.nih.gov/pubmed/27102184?tool=bestpractice.com
These screening tests include a patient’s attempts to swallow small quantities of water or ice chips while being observed by a nurse, a speech-language pathologist, or a physician. Screening tests should be considered whenever aspiration is suspected based on the presence of risk factors. Furthermore, all patients suffering from an acute stroke should undergo a bedside swallow evaluation by a speech-language pathologist, largely because between 40% and 78% of stroke patients have dysphagia.[16]Intercollegiate Stroke Working Party. National clinical guideline for stroke for the UK and Ireland. May 2023 [internet publication].
https://www.strokeguideline.org
[68]Simpson AJ, Allen JL, Chatwin M, et al. BTS clinical statement on aspiration pneumonia. Thorax. 2023 Feb;78(suppl 1):s3-21.
https://thorax.bmj.com/content/78/Suppl_1/s3.long
http://www.ncbi.nlm.nih.gov/pubmed/36863772?tool=bestpractice.com
Dysphagia program studies applied as a result of these screening methods could substantially reduce the rates of pneumonia in stroke patients.[89]Doggett DL, Tappe KA, Mitchell MD, et al. Prevention of pneumonia in elderly stroke patients by systematic diagnosis and treatment of dysphagia: an evidence-based comprehensive analysis of the literature. Dysphagia. Fall 2001;16(4):279-95.
http://www.ncbi.nlm.nih.gov/pubmed/11720404?tool=bestpractice.com
Bedside swallow evaluation
Patients thought to have any risk factors for aspiration should undergo a complete neurologic evaluation before feeding.[90]Marik PE, Kaplan D. Aspiration pneumonia and dysphagia in the elderly. Chest. 2003 Jul;124(1):328-36.
http://www.ncbi.nlm.nih.gov/pubmed/12853541?tool=bestpractice.com
This includes assessing cortical functions, bulbar muscles, gag reflex, and cough reflex. Alert patients with cough who are at high risk of aspiration should be observed drinking small amounts of water. If the patient coughs or shows signs of aspiration, the patient should be referred for a detailed swallowing evaluation.[27]Smith Hammond CA, Goldstein LB. Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(1 suppl):154S-68S.
http://journal.chestnet.org/article/S0012-3692(15)52844-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/16428705?tool=bestpractice.com
Early bedside swallow screening (within 1 day of admission and before any oral intake) and dysphagia management in patients with acute stroke reduces the risk of aspiration pneumonia, may be cost-effective, and may assure quality care with optimal outcome.[91]Odderson IR, Keaton JC, McKenna BS. Swallow management in patients on an acute stroke pathway: quality is cost effective. Arch Phys Med Rehabil. 1995 Dec;76(12):1130-3.
https://www.archives-pmr.org/article/S0003-9993(95)80121-9/pdf
http://www.ncbi.nlm.nih.gov/pubmed/8540789?tool=bestpractice.com
If doubt exists or if silent aspiration is suspected, imaging studies should be performed.[16]Intercollegiate Stroke Working Party. National clinical guideline for stroke for the UK and Ireland. May 2023 [internet publication].
https://www.strokeguideline.org
Phonetic assessment independent of and during the swallow provocation tests may be a useful adjunct to bedside tests for aspiration risk, but it is not validated.[88]Brodsky MB, Suiter DM, González-Fernández M, et al. Screening accuracy for aspiration using bedside water swallow tests: a systematic review and meta-analysis. Chest. 2016 Jul;150(1):148-63.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980548
http://www.ncbi.nlm.nih.gov/pubmed/27102184?tool=bestpractice.com
[92]Festic E, Soto JS, Pitre LA, et al. Novel bedside phonetic evaluation to identify dysphagia and aspiration risk. Chest. 2016 Mar;149(3):649-59.
http://www.ncbi.nlm.nih.gov/pubmed/26203916?tool=bestpractice.com
Although a multitude of other screening tests are available, they have variable sensitivity.[93]Boaden E, Burnell J, Hives L, et al. Screening for aspiration risk associated with dysphagia in acute stroke. Cochrane Database Syst Rev. 2021 Oct 18;10(10):CD012679.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012679.pub2/full
http://www.ncbi.nlm.nih.gov/pubmed/34661279?tool=bestpractice.com
In the opinion of the authors, however, there may be a benefit to obtaining an assessment of aspiration risk from more than one test.
Flexible endoscopic evaluation of swallowing
Flexible endoscopic evaluation of swallowing (FEES) can be performed by speech pathologists at the bedside. With the use of a flexible fiberoptic scope, direct evidence of aspiration is documented by detecting the presence of food or a thick liquid over the vocal cords. The test also assesses the vocal cord function. In a study of critically ill trauma patients, FEES performed within 24 hours after extubation showed aspiration in 45% of the patients, of whom almost half were silent aspirators. These patients resumed an oral diet at a mean of 5 days after extubation and had no pulmonary complications.[50]Leder SB, Cohn SM, Moller BA. Fiberoptic endoscopic documentation of the high incidence of aspiration following extubation in critically ill trauma patients. Dysphagia. Fall 1998;13(4):208-12.
https://link.springer.com/article/10.1007/PL00009573
http://www.ncbi.nlm.nih.gov/pubmed/9716751?tool=bestpractice.com
FEES avoids exposure to radiation; however, modified barium swallow is noninvasive and more widely available.[56]Australian and New Zealand Society for Geriatric Medicine. Position statement abstract: dysphagia and aspiration in older people. Australas J Ageing. 2020 Mar;39(1):85.
http://www.ncbi.nlm.nih.gov/pubmed/31313474?tool=bestpractice.com
[94]American College of Radiology. ACR appropriateness criteria: dysphagia. 2018 [internet publication].
https://acsearch.acr.org/docs/69471/Narrative
Videofluoroscopic swallowing study and modified barium swallow
For these tests, the patient swallows barium under fluoroscopic imaging. Passage or retention of the radiopaque material in the respiratory tract is seen.[16]Intercollegiate Stroke Working Party. National clinical guideline for stroke for the UK and Ireland. May 2023 [internet publication].
https://www.strokeguideline.org
On videofluoroscopic swallowing study, 38% of patients with acute stroke had overt aspiration and 67% had silent aspiration.[95]Daniels SK, Brailey K, Priestly DH, et al. Aspiration in patients with acute stroke. Arch Phys Med Rehabil. 1998 Jan;79(1):14-9.
https://www.archives-pmr.org/article/S0003-9993(98)90200-3/pdf
http://www.ncbi.nlm.nih.gov/pubmed/9440410?tool=bestpractice.com
Modified barium swallow performed in patients with indwelling tracheostomies on positive-pressure ventilation showed an incidence of aspiration of 50%, and 77% of these patients were silent aspirators.[46]Elpern EH, Scott MG, Petro L, et al. Pulmonary aspiration in mechanically ventilated patients with tracheostomies. Chest. 1994 Feb;105(2):563-6.
http://www.ncbi.nlm.nih.gov/pubmed/8306764?tool=bestpractice.com
Emerging assessments for dysphagia
Interventions targeting improved respiratory sensation and respiratory mechanics may prove to be beneficial in patients (such as those with Parkinson disease) who have impaired airway protection.[96]Troche MS, Curtis JA, Sevitz JS, et al. Rehabilitating cough dysfunction in Parkinson's disease: a randomized controlled trial. Mov Disord. 2023 Feb;38(2):201-11.
http://www.ncbi.nlm.nih.gov/pubmed/36345090?tool=bestpractice.com
Various tests of respiratory mechanics have been employed to determine aspiration risk or at least the ability to compensate for a respiratory event. For example, a reduction in the peak cough flow was an independent risk factor for pneumonia.[97]Choi J, Baek S, Kim G, et al. Peak voluntary cough flow and oropharyngeal dysphagia as risk factors for pneumonia. Ann Rehabil Med. 2021 Dec;45(6):431-9.
https://www.e-arm.org/journal/view.php?doi=10.5535/arm.21068
http://www.ncbi.nlm.nih.gov/pubmed/35000368?tool=bestpractice.com
Phonetic screening is a novel technique that may be used to identify dysphagia and aspiration risk at the bedside.[92]Festic E, Soto JS, Pitre LA, et al. Novel bedside phonetic evaluation to identify dysphagia and aspiration risk. Chest. 2016 Mar;149(3):649-59.
http://www.ncbi.nlm.nih.gov/pubmed/26203916?tool=bestpractice.com