Basal cell carcinoma

Monitoring is required in relation to the emergence of basal cell carcinomas (BCCs) in other body areas. Patients who have had one BCC have a ≥30% risk of developing a second BCC.[97]Karagas MR, Stukel TA, Greenberg ER, et al. Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. JAMA. 1992 Jun 24;267(24):3305-10. http://www.ncbi.nlm.nih.gov/pubmed/1597912?tool=bestpractice.com [98]Flohil SC, van der Leest RJ, Arends LR, et al. Risk of subsequent cutaneous malignancy in patients with prior keratinocyte carcinoma: a systematic review and meta-analysis. Eur J Cancer. 2013 Jul;49(10):2365-75. http://www.ncbi.nlm.nih.gov/pubmed/23608733?tool=bestpractice.com ​​ Patients with multiple BCCs are not uncommon. Patients should be monitored, including a complete skin exam, every 6-12 months for the first 5 years, and then at least annually for life.[44]National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer [internet publication]. https://www.nccn.org/professionals/physician_gls/default.aspx

Follow-up with a dermatologist is strongly recommended for patients with any of the following criteria:[44]National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer [internet publication]. https://www.nccn.org/professionals/physician_gls/default.aspx

• Past or imminent solid organ

• Marrow, or hematopoietic cell transplant

• One or more cutaneous melanomas in the past 5 years

• Four or more nonmelanoma skin cancers in the past 5 years

Patients should be evaluated for other solar-induced cancers, such as squamous cell carcinoma of lip and skin, and melanoma.