Cochrane Clinical Answers

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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • How does letrozole compare with other agents for subfertile women with polycystic ovary syndrome (PCOS)?
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  • For women with polycystic ovary syndrome, oligomenorrhea, and subfertility, what are the effects of insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol)?
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  • What are the benefits and harms of adjuvant metformin during ovulation induction with gonadotrophins in women with subfertility associated with polycystic ovary syndrome?
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  • What are the benefits and harms of laparoscopic drilling by diathermy or laser for ovulation induction in women with clomifene‐resistant polycystic ovary syndrome?
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  • In women with polycystic ovary syndrome, how does metformin before and during IVF or ICSI affect outcomes?
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