Prognosis

Eosinophilic esophagitis (EoE) is a chronic disease.[160] However, the prognosis is good. The majority of patients have a good response to either pharmacologic or dietary elimination therapy. If strictures or esophageal narrowing develop, these can be effectively treated with esophageal dilation. 

Approximately one third of patients may be refractory to standard treatments and these patients can be very difficult to treat; often they are referred to clinical trials.[28]​ Studies show that symptoms usually recur when treatment is stopped.[3]

Natural history

The natural history of EoE suggests that, in some patients, chronic eosinophilic inflammation can lead to fibrostenotic remodeling.[5][6][7][35]​​[176]​​[177] Data show that the longer symptoms are present before diagnosis and treatment the more common it is to have esophageal strictures and signs of remodeling.

To date, there has been no association of EoE with esophageal cancer, and no cases of EoE have devolved to a more diffuse eosinophilic gastroenteritis or to hypereosinophilic syndrome.

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