Prognosis
The majority of patients with Noonan syndrome can lead normal lives. Prognosis is largely dependent on the type and severity of cardiac disease. This may occur in up to 75% of cases and is the most common cause of death for people with the syndrome.[1] Pulmonary valve stenosis usually responds well to surgical intervention, but long-term follow-up is required, as obstruction can occur in adulthood.[30] Hypertrophic cardiomyopathy may be benign, may resolve, or may become rapidly progressive with a fatal outcome. Few studies of older adults are reported, but there is some suggestion of late-onset arrhythmias and congestive cardiac failure.[77][78]
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