Type 1 neurofibromatosis

Examples include spinal cord compression from dystrophic scoliosis, lower limb amputation from tibial pseudarthrosis, and ocular proptosis from sphenoid wing dysplasia.

Young patients with optic pathway gliomas subjected to cranial radiotherapy have an increased risk for developing intracranial tumours and moyamoya (a form of angiogenesis in response to blocked arteries in the basal ganglia).[53]Kestle JR, Hoffman HJ, Mock AR. Moyamoya phenomenon after radiation for optic glioma. J Neurosurg. 1993 Jul;79(1):32-5.