Criteria
Serum prolactin level and prolactinoma size
Although a prolactinoma may be associated with any level of serum prolactin, usually the prolactin concentration reflects the size of the prolactinoma.[11] A prolactin level greater than 5000 mIU/L (250 micrograms/L) usually indicates the presence of a prolactinoma; however, some medications (e.g., risperidone, metoclopramide) also elevate prolactin levels.[11] A prolactin level greater than 10,000 mIU/L (500 micrograms/L) is almost certainly a macroprolactinoma.[11] In a patient with a serum prolactin <2000 mIU/L (<100 micrograms/L) and a macroadenoma (pituitary adenoma greater than 10 mm) on pituitary imaging, the diagnosis is likely to be a non-functioning pituitary adenoma causing disconnection hyperprolactinaemia (pituitary stalk compression).[11]
Use of this content is subject to our disclaimer