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3

Endometrial cancer

Histological subtype: clear cell adenocarcinoma (photomicrograph, haematoxylin and eosin stain)

Courtesy of Professor Robert H. Young, Department of Pathology, Massachusetts General Hospital

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4

Endometrial cancer

Grade 1 or low-grade endometrioid adenocarcinoma (right) on background of proliferative endometrium (left); (photomicrograph, haematoxylin and eosin stain)

Courtesy of Professor Robert H. Young, Department of Pathology, Massachusetts General Hospital

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5

Endometrial cancer

Grade 3 or high-grade endometrioid adenocarcinoma on a background of atrophic endometrium (photomicrograph, haematoxylin and eosin stain)

Courtesy of Professor Robert H. Young, Department of Pathology, Massachusetts General Hospital

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1

Endometrial cancer

Histological subtype: endometrioid endometrial adenocarcinoma, the most common subtype; diagnosed on dilation and curettage in a patient presenting with post-menopausal bleeding (photomicrograph, haematoxylin and eosin stain)

Courtesy of Professor Robert H. Young, Department of Pathology, Massachusetts General Hospital

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2

Endometrial cancer

Histological subtype: uterine papillary serous carcinoma with typical small papillae and slit-like spaces.(photomicrograph, haematoxylin and eosin stain)

Courtesy of Professor Robert H. Young, Department of Pathology, Massachusetts General Hospital

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7

Endometrial cancer

Epithelial in situ neoplasia arising in proliferative endometrium (photomicrograph, haematoxylin and eosin stain)

From the collection of George Mutter MD, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School

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6

Endometrial cancer

Low-grade adenocarcinoma arising in proliferative endometrium, stained using immunohistochemistry (brown stain) for phosphatase and tensin homologue protein; note the negatively stained (non-brown) neoplastic glands (normal epithelium usually stains brown)

From the collection of George Mutter MD, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School

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