Last reviewed: 16 Mar 2025
Last updated: 12 Sep 2023
Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- dyspnoea
- syncope
- dizziness
- CHF/pulmonary oedema
- embolic manifestations
- systolic or diastolic murmur
- tumour plop
Other diagnostic factors
- weight loss
- fatigue
- fever
- pallor
- arthralgia
- Raynaud's phenomenon
- loud first heart sound
- opening snap
- Carney's complex
- intra-cerebral aneurysm
Diagnostic investigations
Investigations to consider
- erythrocyte sedimentation rate
- C-reactive protein
- protein electrophoresis
- CT scan (chest)
- MRI scan (chest)
- biopsy
Treatment algorithm
Contributors
Authors
Syed Wamique Yusuf, MBBS, FRCPI

Professor of Medicine
Department of Cardiology
University of Texas MD Anderson Cancer Center
Houston
TX
Disclosures
SWY declares that he has no competing interests.
Acknowledgements
Dr Syed Wamique Yusuf would like to gratefully acknowledge the assistance of Dr Daniel J. Lenihan.
Disclosures
DJL declares that he has no competing interests.
Peer reviewers
Paul Heidenreich, MD
Associate Professor of Medicine
Stanford University
Stanford
CA
Disclosures
PH declares that he has no competing interests.
Richard Steingart, MD
Chief
Cardiology Service
Memorial Sloan-Kettering Cancer Center
New York
NY
Disclosures
RS declares that he has no competing interests.
Barry Kneale, MD, FRCP
Integrated Lead Cardiologist
Western Sussex Hospitals NHS Trust and Cardiac Department
Worthing Hospital
Worthing
UK
Disclosures
BK declares that he has no competing interests.
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