Adultos
A Chlamydia pneumoniae é suscetível a tetraciclinas, macrolídeos e fluoroquinolonas, que são opções de primeira linha equivalentes. A maioria dos estudos de tratamento da pneumonia decorrente da C pneumoniae basearam-se inteiramente do diagnóstico por sorologia; consequentemente, não foi possível avaliar a eficácia microbiológica. Relatórios anedóticos sugeriram que ciclos prolongados de tetraciclinas ou eritromicina, de até 3 semanas, podem ser necessários para erradicar o C pneumoniae da nasofaringe de adultos com faringite e doença semelhante à gripe. Fluoroquinolonas, incluindo o levofloxacino e o moxifloxacino, são muito efetivas no tratamento do C pneumoniae em adultos.[13]Hammerschlag MR, Roblin PM. Microbiologic efficacy of levofloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Antimicrob Agents Chemother. 2000 May;44(5):1409.
http://aac.asm.org/cgi/content/full/44/5/1409
http://www.ncbi.nlm.nih.gov/pubmed/10819727?tool=bestpractice.com
[14]Hammerschlag MR, Roblin PM. Microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Int J Antimicrob Agents. 2000 Jul;15(2):149-52.
http://www.ncbi.nlm.nih.gov/pubmed/10854812?tool=bestpractice.com
Tetraciclinas e fluoroquinolonas não podem ser usadas em gestantes. O tratamento neste grupo deve usar um macrolídeo (azitromicina, claritromicina ou eritromicina). As fluoroquinolonas estão associadas a efeitos adversos graves, incapacitantes e potencialmente irreversíveis, incluindo tendinite, ruptura de tendão, artralgia, neuropatias e outros efeitos sobre os sistemas musculoesquelético ou nervoso.[15]European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. Mar 2019 [internet publication].
https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products
[16]Food and Drug Administration. FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. Mar 2018 [internet publication].
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics
A Food and Drug Administration (FDA) também emitiu avisos sobre o aumento do risco de dissecção de aorta, hipoglicemia significativa e efeitos adversos para a saúde mental em pacientes que tomam fluoroquinolonas.[17]Food and Drug Administration. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. Dec 2018 [internet publication].
https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-increased-risk-ruptures-or-tears-aorta-blood-vessel-fluoroquinolone-antibiotics
[18]Food and Drug Administration. FDA Drug Safety Communication: FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. Jul 2018 [internet publication]
https://www.fda.gov/drugs/drug-safety-and-availability/fda-reinforces-safety-information-about-serious-low-blood-sugar-levels-and-mental-health-side
A maioria dos pacientes apresenta melhora clínica, mesmo com a persistência do organismo.[13]Hammerschlag MR, Roblin PM. Microbiologic efficacy of levofloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Antimicrob Agents Chemother. 2000 May;44(5):1409.
http://aac.asm.org/cgi/content/full/44/5/1409
http://www.ncbi.nlm.nih.gov/pubmed/10819727?tool=bestpractice.com
[19]Block S, Hedrick J, Hammerschlag MR, et al. Mycoplasma pneumoniae and Chlamydia pneumoniae in community acquired pneumonia in children: comparative safety and efficacy of clarithromycin and erythromycin suspensions. Pediatr Infect Dis J. 1995 Jun;14(6):471-7.
http://www.ncbi.nlm.nih.gov/pubmed/7667050?tool=bestpractice.com
[20]Harris J-A, Kolokathis A, Campbell M, et al. Safety and efficacy of azithromycin in the treatment of community acquired pneumonia in children. Pediatr Infect Dis J. 1998 Oct;17(10):865-71.
http://www.ncbi.nlm.nih.gov/pubmed/9802626?tool=bestpractice.com
[21]Roblin PM, Hammerschlag MR. Microbiologic efficacy of azithro-mycin and susceptibility to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community acquired pneumonia. Antimicrob Agents Chemother. 1998 Jan;42(1):194-6.
http://aac.asm.org/cgi/content/full/42/1/194
http://www.ncbi.nlm.nih.gov/pubmed/9449287?tool=bestpractice.com
A persistência não parece ser secundária ao desenvolvimento de resistência a antibióticos.[13]Hammerschlag MR, Roblin PM. Microbiologic efficacy of levofloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Antimicrob Agents Chemother. 2000 May;44(5):1409.
http://aac.asm.org/cgi/content/full/44/5/1409
http://www.ncbi.nlm.nih.gov/pubmed/10819727?tool=bestpractice.com
[14]Hammerschlag MR, Roblin PM. Microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Int J Antimicrob Agents. 2000 Jul;15(2):149-52.
http://www.ncbi.nlm.nih.gov/pubmed/10854812?tool=bestpractice.com
[21]Roblin PM, Hammerschlag MR. Microbiologic efficacy of azithro-mycin and susceptibility to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community acquired pneumonia. Antimicrob Agents Chemother. 1998 Jan;42(1):194-6.
http://aac.asm.org/cgi/content/full/42/1/194
http://www.ncbi.nlm.nih.gov/pubmed/9449287?tool=bestpractice.com
Crianças
O tratamento recomendado é o uso de macrolídeos.[19]Block S, Hedrick J, Hammerschlag MR, et al. Mycoplasma pneumoniae and Chlamydia pneumoniae in community acquired pneumonia in children: comparative safety and efficacy of clarithromycin and erythromycin suspensions. Pediatr Infect Dis J. 1995 Jun;14(6):471-7.
http://www.ncbi.nlm.nih.gov/pubmed/7667050?tool=bestpractice.com
[20]Harris J-A, Kolokathis A, Campbell M, et al. Safety and efficacy of azithromycin in the treatment of community acquired pneumonia in children. Pediatr Infect Dis J. 1998 Oct;17(10):865-71.
http://www.ncbi.nlm.nih.gov/pubmed/9802626?tool=bestpractice.com