Rest alone accounts for the resolution of symptoms in the vast majority of cases. Confusion typically clears within 24 hours in cases of uncomplicated mild traumatic brain injury (TBI) (i.e., no brain lesions found on CT scan) diagnosed in the emergency room.[97]Levin HS, Diaz-Arrastia RR. Diagnosis, prognosis, and clinical management of mild traumatic brain injury. Lancet Neurol. 2015 May;14(5):506-17.
http://www.ncbi.nlm.nih.gov/pubmed/25801547?tool=bestpractice.com
Postconcussion symptoms, including somatic (e.g., headaches, dizziness), cognitive (e.g., poor attention and memory), and emotional (e.g., irritability, depression) symptoms, gradually resolve in most patients with mild TBI during the 12 weeks following injury.[97]Levin HS, Diaz-Arrastia RR. Diagnosis, prognosis, and clinical management of mild traumatic brain injury. Lancet Neurol. 2015 May;14(5):506-17.
http://www.ncbi.nlm.nih.gov/pubmed/25801547?tool=bestpractice.com
However, a subset of patients may have ongoing symptoms. For further details, see Prognosis.
Referral to individual medical specialists or to a specialized multidisciplinary mild TBI clinic is appropriate for patients with persistent symptoms (lasting more than 4-6 weeks) who do not respond to treatment in a primary care setting.[69]US Department of Veterans Affairs. VA/DoD clinical practice guidelines: management and rehabilitation of post-acute mild traumatic brain Injury (mTBI). 2021 [internet publication].
https://www.healthquality.va.gov/guidelines/rehab/mtbi/index.asp
[93]Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 1;172(11):e182853.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006878
http://www.ncbi.nlm.nih.gov/pubmed/30193284?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
All patients with mild TBI should temporarily discontinue activities that present a risk of additional head injury and consequently second impact syndrome.[4]Mayer AR, Quinn DK, Master CL. The spectrum of mild traumatic brain injury: a review. Neurology. 2017 Aug 8;89(6):623-32.
http://www.ncbi.nlm.nih.gov/pubmed/28701496?tool=bestpractice.com
Specifically, to mitigate the risk of repeated mild TBI, patients should be counseled to not return to activities that involve a relatively high risk of head impact exposure (e.g., collision sports) until they are clinically recovered.[94]Giza CC, Kutcher JS, Ashwal S, et al. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2013 Jun 11;80(24):2250-57.
https://n.neurology.org/content/80/24/2250.long
http://www.ncbi.nlm.nih.gov/pubmed/23508730?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
[99]McCrory P, Meeuwisse W, Dvořák J, et al. Consensus statement on concussion in sport - the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med. 2017 Jun;51(11):838-47.
http://bjsm.bmj.com/content/51/11/838.long
Rest
Relative rest for the first 24-48 hours after a mild TBI is recommended.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[93]Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 1;172(11):e182853.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006878
http://www.ncbi.nlm.nih.gov/pubmed/30193284?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
[100]Schneider KJ, Leddy JJ, Guskiewicz KM, et al. Rest and treatment/rehabilitation following sport-related concussion: a systematic review. Br J Sports Med. 2017 Jun;51(12):930-34.
https://bjsm.bmj.com/content/51/12/930
http://www.ncbi.nlm.nih.gov/pubmed/28341726?tool=bestpractice.com
Complete rest, such as lying in a dark room and avoiding all sensory stimuli (e.g., reading, interaction with others, etc.) does not accelerate recovery and is therefore not advisable.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
[100]Schneider KJ, Leddy JJ, Guskiewicz KM, et al. Rest and treatment/rehabilitation following sport-related concussion: a systematic review. Br J Sports Med. 2017 Jun;51(12):930-34.
https://bjsm.bmj.com/content/51/12/930
http://www.ncbi.nlm.nih.gov/pubmed/28341726?tool=bestpractice.com
[101]Silverberg ND, Iverson GL. Is rest after concussion "the best medicine?": recommendations for activity resumption following concussion in athletes, civilians, and military service members. J Head Trauma Rehabil. 2013 Jul-Aug;28(4):250-9.
http://www.ncbi.nlm.nih.gov/pubmed/22688215?tool=bestpractice.com
Physical rest
After an initial period of relative rest and symptom stabilization, patients should be encouraged to gradually resume normal daily activities as tolerated and in a stepwise fashion.[4]Mayer AR, Quinn DK, Master CL. The spectrum of mild traumatic brain injury: a review. Neurology. 2017 Aug 8;89(6):623-32.
http://www.ncbi.nlm.nih.gov/pubmed/28701496?tool=bestpractice.com
[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[93]Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 1;172(11):e182853.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006878
http://www.ncbi.nlm.nih.gov/pubmed/30193284?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
Specific guidelines should be consulted for detailed guidance regarding return to school, sports, and military service.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
[102]McCulloch KL, Goldman S, Lowe L, et al. Development of clinical recommendations for progressive return to activity after military mild traumatic brain injury: guidance for rehabilitation providers. J Head Trauma Rehabil. 2015 Jan-Feb;30(1):56-67.
https://journals.lww.com/headtraumarehab/fulltext/2015/01000/development_of_clinical_recommendations_for.7.aspx
http://www.ncbi.nlm.nih.gov/pubmed/25563414?tool=bestpractice.com
Physical activity/exercise should be stopped if symptom exacerbation is more than mild and brief, and may be resumed once symptoms have returned to the prior levels.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Clinicians should inform their patients that mild symptom exacerbation during physical activity, prescribed aerobic exercise treatment or during cognitive activity is typically brief (under an hour) and does not delay recovery.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Patients can systematically advance their exercise intensity based on the degree of symptom exacerbation experienced during the prior bout of aerobic exercise.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Cognitive rest
Cognitive rest includes school and work activities.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Patients should gradually return to daily activities (including screen time) as tolerated and in a stepwise fashion.[4]Mayer AR, Quinn DK, Master CL. The spectrum of mild traumatic brain injury: a review. Neurology. 2017 Aug 8;89(6):623-32.
http://www.ncbi.nlm.nih.gov/pubmed/28701496?tool=bestpractice.com
[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[93]Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 1;172(11):e182853.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006878
http://www.ncbi.nlm.nih.gov/pubmed/30193284?tool=bestpractice.com
[98]Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020 Feb;101(2):382-93.
https://www.archives-pmr.org/article/S0003-9993(19)31305-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31654620?tool=bestpractice.com
Attentional capacities should be closely monitored, particularly among children. Cognitive exertion should be halted if symptom exacerbation is more than mild and brief, and may be resumed once symptoms have returned to pre-injury levels.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Return to play
Symptoms and signs of mild TBI should be resolved before returning to sport (but absolute physical and cognitive rest after sport-related concussion should be avoided).[3]Harmon KG, Clugston JR, Dec K, et al. American Medical Society for Sports Medicine position statement on concussion in sport. Br J Sports Med. 2019 Feb;53(4):213-25.
https://bjsm.bmj.com/content/53/4/213.long
http://www.ncbi.nlm.nih.gov/pubmed/30705232?tool=bestpractice.com
Return to play is an individualized, gradual, stepwise increase in physical demands and sport-specific activities without return of symptoms before the final introduction of exposure to contact.[3]Harmon KG, Clugston JR, Dec K, et al. American Medical Society for Sports Medicine position statement on concussion in sport. Br J Sports Med. 2019 Feb;53(4):213-25.
https://bjsm.bmj.com/content/53/4/213.long
http://www.ncbi.nlm.nih.gov/pubmed/30705232?tool=bestpractice.com
Light physical activity and prescribed sub-symptom threshold aerobic exercise treatment can be used therapeutically in a safe and supervised environment.[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
[103]Leddy JJ, Master CL, Mannix R, et al. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. Lancet Child Adolesc Health. 2021 Nov;5(11):792-9.
http://www.ncbi.nlm.nih.gov/pubmed/34600629?tool=bestpractice.com
Athletes should also demonstrate psychological readiness for returning to play.[3]Harmon KG, Clugston JR, Dec K, et al. American Medical Society for Sports Medicine position statement on concussion in sport. Br J Sports Med. 2019 Feb;53(4):213-25.
https://bjsm.bmj.com/content/53/4/213.long
http://www.ncbi.nlm.nih.gov/pubmed/30705232?tool=bestpractice.com
Education and return to school/activity/work plan
Explaining to patients the pathophysiology, typical sequelae, recovery timeline, and potential complications is effective in aiding recovery, and in preempting potential anxiety and depression. This should be accompanied by individualized goal-setting for return to, or increase in, activity or work. Patients should be advised on these aspects in the presence of family and care providers.[104]Kelly R. The post-traumatic syndrome: an iatrogenic disease. Forensic Sci. 1975 Aug-Oct;6(1-2):17-24.
http://www.ncbi.nlm.nih.gov/pubmed/1213623?tool=bestpractice.com
[105]Minderhoud JM, Boelens ME, Huizenga J, et al. Treatment of minor head injuries. Clin Neurol Neurosurg. 1980;82(2):127-40.
http://www.ncbi.nlm.nih.gov/pubmed/6254711?tool=bestpractice.com
[106]Mittenberg W, Tremont G, Zielinski RE, et al. Cognitive-behavioral prevention of postconcussion syndrome. Arch Clin Neuropsychol. 1996;11(2):139-45.
http://www.ncbi.nlm.nih.gov/pubmed/14588914?tool=bestpractice.com
Taking appropriately implemented rest breaks throughout the day may be appropriate. Further accommodations may include:[5]Patricios JS, Schneider KJ, Dvorak J, et al. Consensus statement on concussion in sport: the 6th International Conference on concussion in sport-Amsterdam, October 2022. Br J Sports Med. 2023 Jun;57(11):695-711.
https://bjsm.bmj.com/content/57/11/695
http://www.ncbi.nlm.nih.gov/pubmed/37316210?tool=bestpractice.com
Modified school attendance
Frequent rest breaks from cognitive/thinking/deskwork tasks throughout the day
Limited screen time on electronic devices
A reduced workload
Extensions on assignments and projects
Delaying tests and/or permitting additional time to complete them.
Specific considerations for children
Every attempt should be made to keep children and adolescents in school, even if on a modified schedule. This may require close collaboration between physicians, school, and family, and an individualized approach to returning the child to full participation.[93]Lumba-Brown A, Yeates KO, Sarmiento K, et al. Centers for Disease Control and Prevention guideline on the diagnosis and management of mild traumatic brain injury among children. JAMA Pediatr. 2018 Nov 1;172(11):e182853.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006878
http://www.ncbi.nlm.nih.gov/pubmed/30193284?tool=bestpractice.com
Children should never return to play the same day.[37]Halstead ME, Walter KD, Moffatt K, et al. Sport-related concussion in children and adolescents. Pediatrics. 2018 Dec;142(6):e20183074.
https://pediatrics.aappublications.org/content/142/6/e20183074.long
http://www.ncbi.nlm.nih.gov/pubmed/30420472?tool=bestpractice.com
[107]Purcell L. What are the most appropriate return-to-play guidelines for concussed child athletes? Br J Sports Med. 2009 May;43 Suppl 1:i51-5.
http://www.ncbi.nlm.nih.gov/pubmed/19433426?tool=bestpractice.com
Analgesia
Taking analgesics is acceptable, if patients feel it is necessary to help control their headaches. If a patient is able to manage the headache with rest and relaxation, this is always preferable. The management of headaches is along standard lines, but advising patients about the nature and prognosis of mild TBI is important to reduce anxiety which may exacerbate headache symptoms.[55]van Gils A, Stone J, Welch K, et al. Management of mild traumatic brain injury. Pract Neurol. 2020 May;20(3):213-21.
http://www.ncbi.nlm.nih.gov/pubmed/32273394?tool=bestpractice.com
Patients who use pain medication should be cautioned that taking these medications for extended periods of time (≥2 consecutive weeks or more than 15 days per month) is not advised because medication overuse may contribute to headache after mild TBI.[55]van Gils A, Stone J, Welch K, et al. Management of mild traumatic brain injury. Pract Neurol. 2020 May;20(3):213-21.
http://www.ncbi.nlm.nih.gov/pubmed/32273394?tool=bestpractice.com
[108]Wakerley BR. Medication-overuse headache. Pract Neurol. 2019 Oct;19(5):399-403.
http://www.ncbi.nlm.nih.gov/pubmed/31273078?tool=bestpractice.com