Criteria

European Society for Medical Oncology: Classification of favorable cancer of unknown primary (CUP)[2]

  • Single metastatic deposit or oligometastatic disease amenable to local ablative treatment (single-site or oligometastatic CUP)

  • Women with isolated axillary lymph node metastases (breast-like CUP)

  • Women with peritoneal carcinomatosis of a serous papillary adenocarcinoma (ovarian-like CUP)

  • Squamous cell carcinoma involving nonsupraclavicular cervical lymph nodes (head and neck-like CUP)

  • Men with blastic bone metastases and/or immunohistochemistry (IHC) or serum prostate-specific antigen (PSA) expression (prostate-like CUP)

  • Adenocarcinoma with colorectal IHC (CK7-negative, CK20-positive, CDX2-positive) or molecular profile (colon-like CUP)

  • Carcinoma with renal cell histologic and immunohistochemical profile (renal-like CUP).

Eastern Cooperative Oncology Group status[42]

This is a commonly used scale for determining a patient's suitability for aggressive palliative treatment.

Eastern Cooperative Oncology Group: ECOG performance status scale Opens in new window​​

0: Fully active, able to carry on all predisease performance without restriction.

1: Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature (e.g., light housework, office work).

2: Ambulatory and capable of all self-care but unable to carry out any work activities. Up and about more than 50% of waking hours.

3: Capable of only limited self-care, confined to bed or chair more than 50% of waking hours.

4: Completely disabled. Cannot carry on any self-care. Totally confined to bed or chair.

5: Dead.

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