Treatment algorithm

Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer

ACUTE

all patients

Back
1st line – 

symptomatic relief

Treatment is focused on relieving symptoms and decreasing the synovial inflammation. Activity restrictions, and even a short period of bed rest, can be employed.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen can be given for a short time with the appropriate precautions, such as discontinuation with any gastrointestinal symptoms. Ibuprofen has been shown to decrease the duration of symptoms.[20] Ketorolac may be considered in patients with severe pain or those unable to tolerate oral medications. While it is used clinically in children, it is not licensed for use in this patient group. Randomized placebo-controlled trials of ketorolac use in neonate, infant, and child populations are lacking, and data on efficacy and safety are low quality.[21][22]

Acetaminophen may be used if the patient is unable to take NSAIDs.

Aspirin should be avoided due to concern regarding Reye syndrome in pediatric patients.

Use the lowest effective dose for the shortest treatment duration.

Primary options

ibuprofen: children: 5-10 mg/kg orally every 6-8 hours when required, maximum 40 mg/kg/day

OR

naproxen: children ≥2 years of age: 10-20 mg/kg/day orally given in 2-3 divided doses when required

OR

acetaminophen: children: 10-15 mg/kg orally every 4-6 hours when required, maximum 75 mg/kg/day

Secondary options

ketorolac: children ≥6 months of age: consult specialist for guidance on dose

back arrow

Choose a patient group to see our recommendations

Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups. See disclaimer

Use of this content is subject to our disclaimer