The mean incidence of intussusception is 74 per 100,000 among children <1 year of age.[6]Jiang J, Jiang B, Parashar U, et al. Childhood intussusception: a literature review. PLoS One. 2013;8(7):e68482.
https://www.doi.org/10.1371/journal.pone.0068482
http://www.ncbi.nlm.nih.gov/pubmed/23894308?tool=bestpractice.com
Incidence of intussusception can vary significantly by geographic region with more cases occurring in Western Pacific countries (90 per 100,000 children <1 year old) than those in African countries (34 per 100,000 children <1 year old).[7]Clark AD, Hasso-Agopsowicz M, Kraus MW, et al. Update on the global epidemiology of intussusception: a systematic review of incidence rates, age distributions and case-fatality ratios among children aged <5 years, before the introduction of rotavirus vaccination. Int J Epidemiol. 2019 Aug 1;48(4):1316-26.
https://www.doi.org/10.1093/ije/dyz028
http://www.ncbi.nlm.nih.gov/pubmed/30879038?tool=bestpractice.com
In the US, intussusception occurs in 18 to 56 per 100,000 infants.[8]Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.
http://www.ncbi.nlm.nih.gov/pubmed/11099597?tool=bestpractice.com
Most cases occur in children under the age of 12 months. Peak incidence is between 5 and 9 months of age.[6]Jiang J, Jiang B, Parashar U, et al. Childhood intussusception: a literature review. PLoS One. 2013;8(7):e68482.
https://www.doi.org/10.1371/journal.pone.0068482
http://www.ncbi.nlm.nih.gov/pubmed/23894308?tool=bestpractice.com
[8]Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.
http://www.ncbi.nlm.nih.gov/pubmed/11099597?tool=bestpractice.com
[9]Fischer TK, Bihrmann K, Perch M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004 Sep;114(3):782-5.
http://www.ncbi.nlm.nih.gov/pubmed/15342854?tool=bestpractice.com
[10]Samad L, Marven S, El Bashir H, et al. Prospective surveillance study of the management of intussusception in UK and Irish infants. Br J Surg. 2012 Mar;99(3):411-5.
http://www.ncbi.nlm.nih.gov/pubmed/22180094?tool=bestpractice.com
Boys are more commonly affected than girls (ratio 2:1).[8]Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.
http://www.ncbi.nlm.nih.gov/pubmed/11099597?tool=bestpractice.com
[9]Fischer TK, Bihrmann K, Perch M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004 Sep;114(3):782-5.
http://www.ncbi.nlm.nih.gov/pubmed/15342854?tool=bestpractice.com
In the US, racial variation has been demonstrated, with white infants less commonly affected (26-35/100,000) than black infants (30-50/100,000) and infants of other races (112-240/100,000).[8]Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.
http://www.ncbi.nlm.nih.gov/pubmed/11099597?tool=bestpractice.com
Since 1980, rates of intussusception-related hospitalization and intussusception-related death have been decreasing.[8]Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.
http://www.ncbi.nlm.nih.gov/pubmed/11099597?tool=bestpractice.com
[9]Fischer TK, Bihrmann K, Perch M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004 Sep;114(3):782-5.
http://www.ncbi.nlm.nih.gov/pubmed/15342854?tool=bestpractice.com