Prognosis

This chronic condition may remain unresponsive to treatment or may recur once treatments are discontinued. For these patients, symptom relief is important. In one retrospective review of two tertiary care centers in the US, 64% of patients received local therapy, but 30% required ≥2 simultaneous or subsequent nonlocal treatments for adequate control.[22]​​

Many of the treatment options have undesirable side effects that require consideration by practitioners and patients.

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