Lichen planus

International Society of the Study of Vulvovaginal Diseases clinicopathologic diagnostic criteria for vulvar lichen planus[50]Day T, Wilkinson E, Rowan D, et al. Clinicopathologic diagnostic criteria for vulvar lichen planus. J Low Genit Tract Dis. 2020 Jul;24(3):317-29. https://journals.lww.com/jlgtd/fulltext/2020/07000/clinicopathologic_diagnostic_criteria_for_vulvar.16.aspx http://www.ncbi.nlm.nih.gov/pubmed/32205763?tool=bestpractice.com

Provides characteristic clinical and histopathologic features for the diagnosis of erosive, classic, and hypertrophic LP.

Clinicopathologic diagnosis of erosive LP requires all of the following:

• A well-demarcated, glazed red macule or patch, located at the labia minora, vestibule, and/or vagina

• Disease affects hairless skin, mucocutaneous junction, and/or nonkeratinized squamous epithelium

• Degenerative and/or regenerative basal layer damage

• A closely applied band-like lymphocytic infiltrate

• Sclerosis absent

Clinicopathologic diagnosis of erosive classic and hypertrophic LP requires:

• Characteristic clinical appearance accompanied by hyperkeratosis, hypergranulosis, acanthosis, basal layer degeneration, a closely applied lymphocytic infiltrate, and absent dermal sclerosis

• Hypertrophic LP shows marked epithelial abnormality compared with classic LP