Primary prevention
Early diagnosis and intervention based on genetic testing is indicated when there is a family history of inherited thyroid cancer.[4]
Prophylactic thyroidectomy is recommended for carriers of high-risk familial REarranged during Transfection (RET) pathogenic variants (e.g., M918T mutations).[37] Timing of surgery is informed by the aggressiveness of the RET pathogenic variant.[37] Surgery may potentially be deferred in patients with less high risk RET pathogenic variants.
In the case of a nuclear accident, local age-specific guidelines should be immediately consulted regarding potassium iodide prophylaxis.[38] US Department of Health and Human Services: potassium iodide Opens in new window
Secondary prevention
People with a family history of multiple endocrine neoplasia (MEN) type 2A (MEN2A), MEN2B, or isolated familial medullary thyroid cancer should receive genetic counseling and testing.
Use of this content is subject to our disclaimer