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Last reviewed: 16 Mar 2025
Last updated: 31 Jan 2025

Summary

Definition

History and exam

Key diagnostic factors

  • dental pain/toothache
  • thermal sensitivity of teeth
  • fever
  • intraoral and/or extraoral edema
  • intraoral and/or extraoral erythema
  • intraoral and/or extraoral discharge
  • trismus
  • tooth percussion sensitivity
  • mobile teeth
  • deep periodontal pockets, bleeding, gingival recession
  • bone loss around teeth
  • elevated/extruded tooth
  • tachypnea
  • dysphagia/drooling
  • dysphonia
  • dyspnea/respiratory stridor
  • posturing
  • uvular deviation
  • floor of mouth elevation
  • hypotension

Other diagnostic factors

  • halitosis/bad taste in mouth
  • xerostomia
  • neurologic signs

Risk factors

  • poor oral hygiene
  • dental caries
  • periodontal disease
  • partially erupted or impacted tooth
  • dental trauma
  • fractured teeth
  • excessive occlusal wear
  • alcohol or drug misuse
  • low socioeconomic status
  • malnutrition
  • age extremes
  • prior radiation therapy
  • certain medications
  • immunosuppression or comorbidity (higher risk for complications)
  • large dental restorations
  • bruxism
  • prior root canal treatment failure

Diagnostic tests

1st tests to order

  • CBC with differential
  • panoramic radiograph

Tests to consider

  • periapical radiograph
  • CT head and neck (with contrast)
  • infection site aspiration Gram stain/culture and sensitivity
  • CRP
  • ESR
  • serum electrolytes
  • plasma fibrinogen level
  • MRI head and neck
  • ultrasound of fascial spaces
  • electric pulp testing
  • thermal testing
  • blood cultures
  • C-terminal cross-linking telopeptide (CTX)

Treatment algorithm

ACUTE
ONGOING

Contributors

Authors

Melanie S. Lang, DDS, MD
Melanie S. Lang

Associate Professor

Department of Oral and Maxillofacial Surgery

University of Washington School of Dentistry

Seattle

WA

Disclosures

MSL declares that she has no competing interests.

Thomas B. Dodson, DMD, MPH
Thomas B. Dodson

Professor and Chair

Department of Oral and Maxillofacial Surgery

University of Washington School of Dentistry

Seattle

WA

Disclosures

TBD is Editor-in-Chief for the Journal of Oral and Maxillofacial Surgery. He is Chairperson for the Research and Development Commission of the AOCMF for which he receives reimbursement for travel and a per diem. TBD has received a National Institute of Health subaward for research in medication-related osteonecrosis of the jaw. He is a speaker for local and regional study clubs for which he receives honorarium. TBD is also an author of some references cited in this topic.

Peer reviewers

Manish Kumar Bhagania, BDS, MDS

Clinical Associate Professor

Henry M Goldman School of Dental Medicine

Boston University

Boston

MA

Disclosures

MKB declares that he has no competing interests.

Kamran Ali, PhD, MMEd, BDS (Hons), FDSRCS, FCPS, FFDRCSI, FFDTEd, FDSRCPS, PFHEA

National Teaching Fellow

Professor

Faculty of Plymouth Health

University of Plymouth

Plymouth

UK

Disclosures

KA declares that he has no competing interests.

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