Monitoring

Chronic thromboembolic pulmonary hypertension (CTEPH) should be ruled out in patients with persistent dyspnea after acute PE (and 3 months of anticoagulation therapy).[4]​​ Routine screening for CTEPH is not recommended. Indefinite anticoagulation is recommended in patients diagnosed with CTEPH.[4]​​​

There is no single, definitive approach to monitoring parenteral heparin for the management of venous thromboembolism. A suggested approach is to check activated partial thromboplastin time (aPTT) or anti-Xa level every 6 hours until two consecutive therapeutic results are obtained, following which monitoring frequency can be reduced to once daily.[228] Anti-Xa level monitoring may be preferred to aPTT in patients with heparin resistance, prolonged baseline aPTT, or altered heparin responsiveness.[228] A therapeutic range of 0.3 to 0.7 units/mL is suggested when anti-Xa monitoring is used.[228]

Patients treated with a vitamin K antagonist require frequent international normalized ratio (INR) monitoring, preferably at a specialized anticoagulant clinic. However, select patients may be candidates for self-monitoring vitamin K antagonist therapy using portable point-of-care units. Patients on oral anticoagulation who self-monitor or self-manage can improve the quality of their oral anticoagulation therapy.[229]

Dabigatran, rivaroxaban, apixaban, and edoxaban do not require laboratory monitoring with coagulation assays. An assessment of renal function prior to initiating direct oral anticoagulant therapy, and renal and liver function monitoring during therapy, should be conducted as clinically indicated.

Consensus guidance recommends that patients (with venous thromboembolism) receiving low molecular weight heparin should be monitored for signs and symptoms of bleeding and renal function change that necessitates dose adjustment.[228] Complete blood count, platelet count, and serum creatinine should be monitored periodically; routine anti-Xa monitoring is not recommended.[228]

Routine therapeutic drug monitoring of fondaparinux may not be necessary in the majority of patients; anti-Xa assay calibrated for fondaparinux may be considered if fondaparinux accumulation is suspected.[228] 

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