Differentials
Hypophosphatasia
SIGNS / SYMPTOMS
An autosomal recessive disorder that radiographically resembles rickets.
This is an inborn error of metabolism in which activity of the tissue-non-specific (liver/bone/kidney) alkaline phosphatase is deficient.[5]
INVESTIGATIONS
Defined by low serum alkaline phosphatase activity.
Large quantities of phosphoethanolamine are found in the urine.
Metaphyseal dysostoses
SIGNS / SYMPTOMS
Includes Jansen and Schmid types of metaphyseal dysostosis and Pyle's disease.
Bowing of the legs, short stature, and a waddling gait.[5]
INVESTIGATIONS
Absence of abnormalities of low serum levels of calcium and phosphate, alkaline phosphatase activity, or vitamin D metabolites.
Blount syndrome
SIGNS / SYMPTOMS
Condition that causes osteochondrosis of the tibia, resulting in bowing of the legs. May be related to obesity.
INVESTIGATIONS
Absence of abnormalities of low serum levels of calcium and phosphate, alkaline phosphatase activity, or vitamin D metabolites.
Benign hyperphosphatasia
SIGNS / SYMPTOMS
A benign condition of elevations of serum alkaline phosphatase levels. May be transient or permanent.
INVESTIGATIONS
Absence of radiological findings of rickets.
Chronic renal failure
SIGNS / SYMPTOMS
Chronic renal failure can cause a rickets-like clinical picture, but this is rarely a presenting finding.
INVESTIGATIONS
Abnormal renal function tests.
Use of this content is subject to our disclaimer