Criteria
Radiological diagnostic requirements[3]
Rickets is diagnosed by the presence of x-ray findings including long bone cupping, splaying, and fraying of the metaphyseal areas. Looser's zones (pseudofractures) may also be seen in areas of decreased calcification where major arteries cross bone.
Biochemical diagnostic requirements[25]
An elevated alkaline phosphatase level is present in active rickets and normal in recovering rickets of any aetiology. A low 25-hydroxyvitamin D level in the presence of active rickets defines vitamin D deficient rickets. A low percent tubular reabsorption of phosphate (TRP) in the absence of vitamin D deficiency is diagnostic of hypophosphataemic rickets.
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