Complications
Over-replacement of glucocorticoids can lead to development of signs and symptoms of Cushing syndrome (weight gain and facial plethora). The likelihood of Cushing syndrome depends on the glucocorticoid dose.
Glucocorticoid dose should be tapered down to avoid development of iatrogenic Cushing syndrome.
Associated with long-term excessive glucocorticoid replacement.
The likelihood of osteoporosis depends on the glucocorticoid dose. Physiological replacement doses do not result in osteopenia/osteoporosis. If decreased bone density is detected in patients receiving supra-physiological doses and no other cause for bone loss can be identified (e.g., menopause), the glucocorticoid dose should be decreased.
Excessive mineralocorticoid replacement manifests with hypertension and hypokalaemia.
Dose should be adjusted.
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