Case history
Case history #1
A 79-year-old man presents with dyspnoea on exertion for 1 year and lower extremity oedema. As part of a cardiac evaluation, the echocardiogram shows concentric left ventricular hypertrophy. Cardiac catheterisation shows normal coronary arteries and he is referred for further evaluation of non-cardiac dyspnoea.
Case history #2
A 62-year-old man is referred for management of atypical multiple myeloma. He has mild anaemia (haemoglobin 12 g/dL) and urinary protein loss of 2.2 g/day. Urine immunofixation electrophoresis shows free lambda light chains. Bone marrow examination shows 5% plasma cells and does not fulfil criteria for multiple myeloma.
Other presentations
Patients with amyloidosis may present with unexplained cardiomyopathy, non-diabetic proteinuria, unexplained hepatomegaly, axonal or demyelinating peripheral neuropathy with autonomic features, or atypical multiple myeloma.
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