When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Last reviewed: 15 Mar 2025
Last updated: 22 Jun 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • headache
  • photophobia
  • neck stiffness
  • fever
  • nausea and vomiting

Other diagnostic factors

  • rash
  • Kernig's sign
  • Brudzinski's sign

Risk factors

  • infants and young children
  • young adults
  • older people
  • summer and autumn
  • exposure to mosquito or tick vector
  • unvaccinated for mumps
  • use of swimming pools and ponds
  • immunosuppression
  • exposure to rodents

Diagnostic investigations

1st investigations to order

  • blood cultures
  • FBC and differential
  • C-reactive protein (CRP)
  • serum procalcitonin
  • serum urea, creatinine, and electrolytes
  • blood gases
  • blood glucose
  • CSF microscopy
  • CSF Gram stain
  • CSF bacterial culture
  • CSF protein
  • CSF glucose
  • CSF lactate
  • CSF, stool and throat swab PCR for viral pathogens
  • HIV serology/HIV reverse transcriptase (RT)-PCR

Treatment algorithm

Contributors

Expert advisers

John Williams, MRCP, DTM&H

Infectious Diseases Consultant

The James Cook University Hospital

Middlesbrough

UK

Disclosures

JW declares that he has no competing interests.

Acknowledgements

Dr John Williams would like to gratefully acknowledge Dr David Chadwick, a previous contributor to this topic.

Disclosures

DC is an author of a reference cited in this topic.

Peer reviewers

Alex Alexiou, MBBS, BSc, DCH, FRCEM, Dip IMC RCSEd

Consultant in Emergency Medicine

Royal London Hospital

Consultant, Physician Response Unit

Barts Health NHS Trust/London Air Ambulance

London

UK

Disclosures

AA declares that he has no competing interests.

Fiona McGill, MRCP, DTMH, DipHIVMed

Clinical Lecturer

Institute of Infection and Global Health

University of Liverpool

Liverpool

UK

Disclosures

FM is on the Meningitis Research Foundation’s Medical Advisory Group, has lectured on national and international events on meningitis and has developed a review for ‘clinical medicine’ on viral meningitis and encephalitis.

Use of this content is subject to our disclaimer