Outcome in most people with viral meningitis is generally good. However, headache and malaise may persist for weeks in adults, particularly following meningitis caused by herpes simplex virus.[6]McGill F, Griffiths MJ, Bonnett LJ, et al. Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infect Dis. 2018 Sep;18(9):992-1003.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30245-7/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/30153934?tool=bestpractice.com
[36]Rotbart HA, Brennan PJ, Fife KH. Enterovirus meningitis in adults. Clin Infect Dis. 1998 Oct;27(4):896-8.
http://www.ncbi.nlm.nih.gov/pubmed/9798053?tool=bestpractice.com
Long-term neurological damage is extremely uncommon, but subtle neuro-developmental deficits have been described in infants who have recovered from enteroviral meningitis.[75]Wilfert CM, Thompson RJ Jr, Sunder TR, et al. Longitudinal assessment of children with enteroviral meningitis during the first 3 months of life. Pediatrics. 1981 Jun;67(6):811-5.
http://www.ncbi.nlm.nih.gov/pubmed/7232044?tool=bestpractice.com
[76]Bedford H, de Louvais J, Halket S, et al. Meningitis in infancy in England and Wales: follow up at age 5 years. BMJ. 2001 Sep 8;323(7312):533-6.
https://www.bmj.com/content/323/7312/533.long
http://www.ncbi.nlm.nih.gov/pubmed/11546697?tool=bestpractice.com
[77]Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol. 2020 Mar;30(2):e2083.
http://www.ncbi.nlm.nih.gov/pubmed/31524309?tool=bestpractice.com
In contrast, follow-up of children after meningitis due to enterovirus-71 has demonstrated no neuro-developmental problems.[77]Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol. 2020 Mar;30(2):e2083.
http://www.ncbi.nlm.nih.gov/pubmed/31524309?tool=bestpractice.com
[78]Chang LY, Huang LM, Gau SS, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007 Mar 22;356(12):1226-34.
https://www.nejm.org/doi/10.1056/NEJMoa065954
http://www.ncbi.nlm.nih.gov/pubmed/17377160?tool=bestpractice.com
Viral meningitis may recur. Enteroviral infection induces protective immunity but will not prevent infection with different serotypes. Meningitis due to herpes simplex virus type 2 (HSV-2) recurs in about 20% of patients.[22]Bergstrom T, Vahlne A, Alestig K, et al. Primary and recurrent herpes simplex virus type 2-induced meningitis. J Infect Dis. 1990 Aug;162(2):322-30.
http://www.ncbi.nlm.nih.gov/pubmed/2165105?tool=bestpractice.com
Recurrent benign lymphocytic meningitis (also known as Mollaret's meningitis) is a rare condition thought to be due to viral infection.