Acute cervical spine trauma in adults
- Overview
- Theory
- Diagnosis
- Management
- Follow up
- Resources
Treatment algorithm
Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer
Look out for this icon: for treatment options that are affected, or added, as a result of your patient's comorbidities.
suspected cervical spine injury
1st line – stabilisation of the patient (including a primary survey)
stabilisation of the patient (including a primary survey)
Use the Advanced Trauma Life Support protocol to assess and stabilise any patient with suspected trauma. Start with a rapid primary survey using a <C>ABCDE approach:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41 [24]Committee on Trauma, American College of Surgeons. ATLS: Advanced trauma life support program for doctors. 10th ed. Chicago, IL: American College of Surgeons; 2018.
Catastrophic haemorrhage
Airway with in-line spinal immobilisation
Breathing
Circulation
Disability (neurological)
Exposure and environment.
Protect the patient's cervical spine with manual in-line spinal immobilisation (particularly during any airway intervention) at all stages of the assessment for spinal injury (see Diagnosis recommendations section) or if the assessment cannot be done.[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41 If you suspect a head injury, see our topic Assessment of traumatic brain injury.
full in-line spinal immobilisation
Additional treatment recommended for SOME patients in selected patient group
Carry out and maintain (until the spine is cleared) full in-line spinal immobilisation if the patient has:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
A high-risk factor for cervical spine injury by the Canadian C-spine rule
A low-risk factor for cervical spine injury by the Canadian C-spine rule AND the patient is unable to actively rotate their neck 45 degrees to both left and right
Do not carry out or maintain full in-line spinal immobilisation if the patient:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Has low-risk factors for cervical spine injury by the Canadian C-spine rule AND
Is pain free AND
Is able to actively rotate their neck 45 degrees to both left and right.
[Figure caption and citation for the preceding image starts]: Canadian C-spine rule. A&E, accident and emergency department; GCS, Glasgow Coma Scale; MVC, Motor vehicle collision. ✝Adapted from Stiell IG, et al. The Canadian C-spine rule for radiography in alert and stable trauma patients. JAMA. 2001 17;286(15):1841-8. [Citation ends].
The UK’s National Institute for Health and Care Excellence recommends CT scanning first line in adults who are identified by the Canadian C-spine rule as requiring imaging.[14]National Institute for Health and Care Excellence. Head injury: assessment and early management. May 2023 [internet publication]. https://www.nice.org.uk/guidance/ng232
When immobilising the spine, manually stabilise the head with the spine in-line using the following stepwise approach.[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Fit an appropriately sized, semi-rigid collar unless contraindicated by:
A compromised airway
Known spinal deformities, such as ankylosing spondylitis (in these patients keep the spine in the patient's current position)
Reassess the airway after applying the collar
Secure the patient with head blocks and tape.
Practical tip
Do not attempt to put a collar on a patient who is holding their neck in a fixed position (e.g., a person with ankylosing spondylitis). You may need to allow patients who are uncooperative, agitated, or distressed to assume a position they find comfortable for manual in-line mobilisation.
Practical tip
Cervical spine immobilisation is associated with adverse effects (e.g., raised intracranial pressure, pain, pressure sores). You should remove collars as soon as is safe and feasible (i.e., as soon as the cervical spine has been cleared by the CT scan, if no abnormalities have been identified).
For patients with suspected thoracic or lumbosacral spine injury see our topic Thoracolumbar spine trauma.
analgesia
Treatment recommended for ALL patients in selected patient group
Offer medications to control pain in the acute phase in patients with a suspected spinal injury:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Use intravenous morphine as the first-line analgesic, adjusting the dose as needed to maintain adequate pain relief
If intravenous access has not been established, consider diamorphine or ketamine via the intranasal route (follow local protocols)
Consider intravenous ketamine, given in analgesic doses, as a second-line option.
Practical tip
Do not use the following medications, aimed at providing neuroprotection and prevention of secondary deterioration, in the acute stage in patients with a spinal cord injury:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Methylprednisolone
Nimodipine
Naloxone.
Do not use medications in the acute stage in patients with a spinal cord injury to prevent neuropathic pain from developing in the chronic stage.[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Primary options
morphine sulfate: 5-10 mg intravenously every 4 hours initially, adjust dose according to response
Secondary options
diamorphine: consult specialist for guidance on intranasal dose
More diamorphineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
OR
ketamine: consult specialist for guidance on intranasal dose
More ketamineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
Tertiary options
ketamine: consult specialist for guidance on intravenous dose
These drug options and doses relate to a patient with no comorbidities.
Primary options
morphine sulfate: 5-10 mg intravenously every 4 hours initially, adjust dose according to response
Secondary options
diamorphine: consult specialist for guidance on intranasal dose
More diamorphineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
OR
ketamine: consult specialist for guidance on intranasal dose
More ketamineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
Tertiary options
ketamine: consult specialist for guidance on intravenous dose
Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.
Show drug information for a patient with no comorbidities
Primary options
morphine sulfate
Secondary options
diamorphine
OR
ketamine
Tertiary options
ketamine
confirmed cervical spine injury
urgent specialist referral
Seek urgent advice from a neurosurgeon or spinal surgeon for any patient with a cervical spine injury confirmed on imaging.[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41 [27]British Orthopaedic Association Standards for Trauma (BOAST). Cervical spine clearance in the trauma patient. May 2021 [internet publication]. https://www.boa.ac.uk/resource/boast-cervical-spine-clearance-in-the-trauma-patient.html
analgesia
Treatment recommended for ALL patients in selected patient group
Offer medications to control pain in the acute stage:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Use intravenous morphine as the first-line analgesic, adjusting the dose as needed to maintain adequate pain relief
If intravenous access has not been established, consider diamorphine or ketamine via the intranasal route (follow local protocols)
Consider intravenous ketamine, given in analgesic doses, as a second-line option.
Practical tip
Do not use the following medications, aimed at providing neuroprotection and prevention of secondary deterioration, in the acute stage in patients with a spinal cord injury:[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Methylprednisolone
Nimodipine
Naloxone.
Do not use medications in the acute stage in patients with a spinal cord injury to prevent neuropathic pain from developing in the chronic stage.[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Primary options
morphine sulfate: 5-10 mg intravenously every 4 hours initially, adjust dose according to response
Secondary options
diamorphine: consult specialist for guidance on intranasal dose
More diamorphineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
OR
ketamine: consult specialist for guidance on intranasal dose
More ketamineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
Tertiary options
ketamine: consult specialist for guidance on intravenous dose
These drug options and doses relate to a patient with no comorbidities.
Primary options
morphine sulfate: 5-10 mg intravenously every 4 hours initially, adjust dose according to response
Secondary options
diamorphine: consult specialist for guidance on intranasal dose
More diamorphineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
OR
ketamine: consult specialist for guidance on intranasal dose
More ketamineIntranasal dosing can be achieved by using the solution for injection. Some protocols use a syringe with an atomiser attached. Follow local protocols for preparing the dose. This is an unlicensed indication.
Tertiary options
ketamine: consult specialist for guidance on intravenous dose
Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.
Show drug information for a patient with no comorbidities
Primary options
morphine sulfate
Secondary options
diamorphine
OR
ketamine
Tertiary options
ketamine
simple neck sprain injury or whiplash
analgesia
Offer oral analgesics to patients with a simple neck sprain injury (i.e., injury to the neck where there has been no demonstrable bony injury or unstable ligamentous injury) or whiplash.
Start with paracetamol. If pain relief is inadequate, replace paracetamol with a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen.
Give a weak opioid (e.g., codeine, tramadol) to patients who cannot take an NSAID.
The UK Medicines and Healthcare products Regulatory Agency (MHRA) advises that opioids should be used with caution as there is an increased risk of tolerance, dependence, and addiction, especially with prolonged use (longer than 3 months). The dose should be tapered slowly at the end of treatment to minimise the risk of withdrawal reactions.[35]Medicines and Healthcare products Regulatory Agency. Opioids: risk of dependence and addiction. September 2020 [internet publication]. https://www.gov.uk/drug-safety-update/opioids-risk-of-dependence-and-addiction
Primary options
paracetamol: 500-1000 mg orally every 4-6 hours when required, maximum 4000 mg/day
Secondary options
ibuprofen: 300-600 mg orally (immediate-release) every 6-8 hours when required, maximum 2400 mg/day
Tertiary options
codeine phosphate: 30-60 mg orally every 4 hours when required, maximum 240 mg/day
OR
tramadol: 100 mg orally (immediate-release) initially, followed by 50-100 mg every 4-6 hours when required; maximum 400 mg/day; 50-100 mg intravenously every 4-6 hours when required
These drug options and doses relate to a patient with no comorbidities.
Primary options
paracetamol: 500-1000 mg orally every 4-6 hours when required, maximum 4000 mg/day
Secondary options
ibuprofen: 300-600 mg orally (immediate-release) every 6-8 hours when required, maximum 2400 mg/day
Tertiary options
codeine phosphate: 30-60 mg orally every 4 hours when required, maximum 240 mg/day
OR
tramadol: 100 mg orally (immediate-release) initially, followed by 50-100 mg every 4-6 hours when required; maximum 400 mg/day; 50-100 mg intravenously every 4-6 hours when required
Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.
Show drug information for a patient with no comorbidities
Primary options
paracetamol
Secondary options
ibuprofen
Tertiary options
codeine phosphate
OR
tramadol
discharge plus advice
Treatment recommended for ALL patients in selected patient group
Discharge patients who have either no indications for a CT scan (as identified by the Canadian C-spine rule) or a normal CT scan, if they are able to rotate their neck 45 degrees to both left and right and do not have severe neck pain (≥7/10 severity).[13]National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. Feb 2016 [internet publication]. https://www.nice.org.uk/guidance/ng41
Advise patients to immediately return to the accident and emergency department if they develop any new neurological symptoms or signs.[33]Royal College of Emergency Medicine. Exclusion of significant cervical spine injury in alert, adult patients with potential blunt neck trauma in the emergency department. November 2010 [internet publication]. https://www.rcem.ac.uk/docs/College%20Guidelines/5z18.%20Practical%20guide%20-%20a%20short%20summary%20of%20the%20above%20c-spine%20guideline.pdf
Choose a patient group to see our recommendations
Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups. See disclaimer
Use of this content is subject to our disclaimer