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Last reviewed: 13 Mar 2025
Last updated: 18 Sep 2024

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • withdrawal
  • tolerance
  • increased/decreased liver size, jaundice, ascites

Other diagnostic factors

  • insomnia
  • erectile dysfunction
  • nicotine-use disorder
  • gastrointestinal distress
  • muscle cramps, pain, tenderness, altered sensory perception
  • hypertension and tachycardia
  • impaired nutritional status
  • broad-based gait

Risk factors

  • family history of alcohol-use disorder
  • antisocial behaviour (pre-morbid)
  • high trait anxiety level
  • lack of facial flushing on exposure to alcohol
  • low responsivity to the effects of alcohol
  • history of gastric bypass

Diagnostic investigations

1st investigations to order

  • diagnostic interview
  • alcohol level (breath and blood)
  • Clinical Institute Withdrawal Assessment for Alcohol, revised (CIWA-Ar)

Investigations to consider

  • carbohydrate-deficient transferrin (CDT)
  • gamma glutamyl transpeptidase (gamma-GT), alanine aminotransferase (ALT), aspartate aminotransferase (AST)
  • FBC
  • urinary ethyl glucuronide

Treatment algorithm

Contributors

Authors

Elisabeth Poorman, MD, MPH

​Assistant Professor of Medicine

Department of Medicine

University of Illinois Chicago

Chicago

IL

Disclosures

EP declares that she has no conflicting interests.

Marlene Martin, MD

Associate Professor of Clinical Medicine

Director, Addiction Care Team

San Francisco General Hospital

University of California, San Francisco

San Francisco

CA

Disclosures

MM is a board member for the National Harm Reduction Coalition and has done consultancy work for the Society of Hospital Medicine.

Sarah Messmer, MD

​Assistant Professor of Clinical Medicine and Pediatrics

University of Illinois Chicago

Chicago

IL

Disclosures

SM declares that she has no conflicting interests.

Acknowledgements

Dr Elisabeth Poorman, Dr Marlene Martin, and Dr Sarah Messmer would like to gratefully acknowledge Dr Colin Drummond, Dr Julie R. Pittman, Dr Philip H. Chung, Dr Robert M. Swift, and Dr Lorenzo Leggio, previous contributors to this topic.

Disclosures

CD, JRP, PHC, and RMS declare that they have no competing interests. LL is an author of a reference cited in this topic.

Peer reviewers

Paul S. Haber, MD

Royal Prince Alfred Hospital and Discipline of Medicine

University of Sydney

Sydney

Australia

Disclosures

PSH is an author of a reference cited in this topic.

Roberta Agabio, MD

Bernard B. Brodie Department of Neuroscience

University of Cagliari

Cagliari

Italy

Disclosures

RA is an author of a number of references cited in this topic.

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