Epidemiology

In the US, incidence of primary myelofibrosis (PMF) is reported to be 0.44 per 100,000 person-years (data from 2002 to 2016).[4] In the UK, annual incidence of PMF is estimated to be 0.6 per 100,000, with an estimated 380 people newly diagnosed each year (data from 2010 to 2019).[5] In Europe, incidence is reported to be between 0.1 to 1 per 100,000 persons per year.[6]

PMF occurs more commonly in males (male to female rate ratio approximately 1.8 in the US, and 1.6 in the UK).[4][5] Incidence in the US is reported to be highest among white people.[4] PMF more commonly affects older people (approximately 66% of patients in the US are age ≥65 years at diagnosis), but younger people may develop the disease.[4] Median age at diagnosis is 70 years in the US, and 73 years in the UK.[4][5]

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