Descolamento de retina

Terapia medicamentosa intravítrea adjuvante

As evidências para prevenção da vitreorretinopatia proliferativa pós-operatória (uma causa de fracasso da cirurgia para recolagem da retina) com heparina de baixo peso molecular isolada, ou com fluoruracila, são inconsistentes.[58]Sundaram V, Barsam A, Virgili G. Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD006421. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006421.pub3/full http://www.ncbi.nlm.nih.gov/pubmed/23440808?tool=bestpractice.com Um ensaio clínico duplo-cego randomizado está em andamento para avaliar o efeito preventivo de fluoruracila e da heparina intravítrea em pacientes de alto risco com descolamento de retina.[59]Schaub F, Hoerster R, Schiller P, et al. Prophylactic intravitreal 5-fluorouracil and heparin to prevent proliferative vitreoretinopathy in high-risk patients with retinal detachment: study protocol for a randomized controlled trial. Trials. 2018 Jul 16;19(1):384. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048849 http://www.ncbi.nlm.nih.gov/pubmed/30012187?tool=bestpractice.com [60]US National Library of Medicine. ​Prophylactic intravitreal 5-fluorouracil and heparin to prevent PVR in high-risk patients with retinal detachment. Apr 2022 [internet publication]. https://clinicaltrials.gov/ct2/show/NCT02834559?term=NCT02834559&draw=2&rank=1