Criteria
Diagnosis criteria[35]
Bone marrow hypocellular, with no abnormal cells and no fibrosis.
At least two among the following:
Hemoglobin <10 g/dL
Platelet count <50 × 10⁹/L
Absolute neutrophil count <1.5 × 10⁹/L.
Severity criteria[36][37]
Severe AA
Bone marrow cellularity <25% or cellularity <50% with <30% residual hematopoietic cells
At least 2 among the following:
Absolute reticulocyte count <20 × 10⁹/L (<60 × 10⁹/L using an automated analysis)
Platelet count <20 × 10⁹/L
Absolute neutrophil count <0.5 × 10⁹/L.
Very severe AA
Absolute neutrophil count <0.2 × 10⁹/L
AND fulfills the rest of the criteria for severe AA.
Non-severe AA
Patients not fulfilling the criteria for severe or very severe AA.
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